{"created":"2023-05-15T09:02:33.370551+00:00","id":3407,"links":{},"metadata":{"_buckets":{"deposit":"00a30729-e0f3-4498-835a-a8b88305c93a"},"_deposit":{"created_by":3,"id":"3407","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3407"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003407","sets":["557:558:559"]},"author_link":["9774","9789","9613","9611","9748","9758","9455","9773","9449","9618","9467","9610","9717","9622","9458","9716","9363","9438","9706","9756","9440","9787","9728","9447","9788","9772","9760","9734","9365","9785","9364","9626","9757","9775","9439","9359","9759","9741","9790","9351","9727","9464","9791","9355","9754","9770","9705"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"A study on the prevention of congenital malformation caused by antiepileptic drug therapy during pregnancy."}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"コウテンカンヤク ニヨル キケイ ハツゲン ボウシ ニ カンスル ケンキュウ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1991-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"94","bibliographicPageStart":"88","bibliographicVolumeNumber":"22","bibliographic_titles":[{"bibliographic_title":"精神薬療基金研究年報"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"抗てんかん薬(AED)による奇形発現防止のため,その発現に関連すると考えられる各種危険要因の相対的重要性およびAEDによる奇形防止の可能性を検討した.対象は従来からのAED療法を受けたてんかん妊婦とその児192例(A群)と妊娠前にAED投薬量を少なくし,かつ可能な限り多剤併用から単剤投与へとdrug regimenを変更したてんかん妊婦とその児145例(B群)である.A,B両群の奇形発現率はそれぞれ13.5%,6.2%であり,両群間には有意差が認められた(p=0.031).妊婦の出産時年齢,てんかんの病因,てんかん発作型での頻度がA群,B群問で有意に異なっていた(p<0.05).またAED投与剤数がB群で有意に少なく(p=near O),1日当たりのAED総投与量(drug score)も有意に(p=0.042)少なかった.出産時年齢,てんかんの病因,てんかん発作型での各カテゴリーで奇形発現率を補正してもB群の奇形発現率は有意に低かったが,drug scoreまたはAED投与剤数で補正すると,A,B両群間の奇形発現率に有意差は認められなかった.以上の結果から,奇形発現が13.5%から6.2%へ減少した主な原因はAED関連要因に由来し,AED投与法の改善により奇形発現はかなり防止可能と考えられた.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"精神薬療基金研究年報. 22, 1991, p.88-94","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9355","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カネコ, スナオ"}]},{"nameIdentifiers":[{"nameIdentifier":"9455","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オオタニ, コウイチ"}]},{"nameIdentifiers":[{"nameIdentifier":"9458","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヒラノ, タカユキ"}]},{"nameIdentifiers":[{"nameIdentifier":"9364","nameIdentifierScheme":"WEKO"}],"names":[{"name":"コンドウ, ツヨシ"}]},{"nameIdentifiers":[{"nameIdentifier":"9439","nameIdentifierScheme":"WEKO"}],"names":[{"name":"フクシマ, ユタカ"}]},{"nameIdentifiers":[{"nameIdentifier":"9741","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オガワ, ヨシヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"9770","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナカムラ, ユキオ"}]},{"nameIdentifiers":[{"nameIdentifier":"9622","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サイトウ, ヨシハル"}]},{"nameIdentifiers":[{"nameIdentifier":"9772","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カン, ルミコ"}]},{"nameIdentifiers":[{"nameIdentifier":"9773","nameIdentifierScheme":"WEKO"}],"names":[{"name":"クマシロ, ヒサシ"}]},{"nameIdentifiers":[{"nameIdentifier":"9774","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ツイキ, ヒトシ"}]},{"nameIdentifiers":[{"nameIdentifier":"9775","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ツルサキ, マサヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"9611","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナカネ, ヨシブミ"}]},{"nameIdentifiers":[{"nameIdentifier":"9716","nameIdentifierScheme":"WEKO"}],"names":[{"name":"テラニシ, タカシ"}]},{"nameIdentifiers":[{"nameIdentifier":"9717","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ゴトウ, マサシ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9359","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kaneko, Sunao"}]},{"nameIdentifiers":[{"nameIdentifier":"9464","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Otani, Koichi"}]},{"nameIdentifiers":[{"nameIdentifier":"9467","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hirano, Takayuki"}]},{"nameIdentifiers":[{"nameIdentifier":"9365","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kondo, Tsuyoshi"}]},{"nameIdentifiers":[{"nameIdentifier":"9440","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Fukushima, Yutaka"}]},{"nameIdentifiers":[{"nameIdentifier":"9748","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ogawa, Yoshihiro"}]},{"nameIdentifiers":[{"nameIdentifier":"9785","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nakamura, Yukio"}]},{"nameIdentifiers":[{"nameIdentifier":"9618","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Saito, Yoshiharu"}]},{"nameIdentifiers":[{"nameIdentifier":"9787","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kan, Rumiko"}]},{"nameIdentifiers":[{"nameIdentifier":"9788","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kumashiro, Hisashi"}]},{"nameIdentifiers":[{"nameIdentifier":"9789","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Takeda, Akio"}]},{"nameIdentifiers":[{"nameIdentifier":"9790","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tuiki, Hitoshi"}]},{"nameIdentifiers":[{"nameIdentifier":"9791","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Turusaki, Masahiro"}]},{"nameIdentifiers":[{"nameIdentifier":"9610","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Nakane, Yoshibumi"}]},{"nameIdentifiers":[{"nameIdentifier":"9727","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Teranishi, Takashi"}]},{"nameIdentifiers":[{"nameIdentifier":"9728","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Goto, Masashi"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"精神神経系薬物治療研究基金"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_relation_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"ＡＮ00128340","subitem_relation_type_select":"NCID"}}]},"item_3_rights_14":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"本文データは財団法人先進医薬研究振興財団の許諾に基づき複製したものである。"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.7","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前大学医学部神経精神科学教室"},{"subitem_text_value":"弘前大学医学部神経精神科学教室"},{"subitem_text_value":"弘前大学医学部神経精神科学教室"},{"subitem_text_value":"弘前大学医学部神経精神科学教室"},{"subitem_text_value":"弘前大学医学部神経精神科学教室"},{"subitem_text_value":"弘前大学医学部産婦人科学教室"},{"subitem_text_value":"弘前大学医学部産婦人科学教室"},{"subitem_text_value":"弘前大学医学部産婦人科学教室"},{"subitem_text_value":"福島県立医科大学医学部神経精神科学教室"},{"subitem_text_value":"福島県立医科大学医学部神経精神科学教室"},{"subitem_text_value":"国立名古屋病院・内科"},{"subitem_text_value":"長崎大学医学部精神神経科学教室"},{"subitem_text_value":"長崎大学医学部精神神経科学教室"},{"subitem_text_value":"塩野義解析センター"},{"subitem_text_value":"塩野義解析センター"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"兼子, 直"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大谷, 浩一"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"平野, 敬之"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"近藤, 毅"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"福島, 裕"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小川, 克弘"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中村, 幸夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"齊藤, 良治"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"管, るみ子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"熊代, 永"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"武田, 明夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"立木, 均"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"鶴崎, 昌弘"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中根, 充文"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"寺西, 孝司"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"後藤, 昌司"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"SeishinYakuryoNenpo_22_88.pdf","filesize":[{"value":"358.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"SeishinYakuryoNenpo_22_88.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3407/files/SeishinYakuryoNenpo_22_88.pdf"},"version_id":"1d683859-60ca-4cb7-acf1-88caa5b00250"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"antiepileptic drug","subitem_subject_scheme":"Other"},{"subitem_subject":"dose","subitem_subject_scheme":"Other"},{"subitem_subject":"congenital malformation","subitem_subject_scheme":"Other"},{"subitem_subject":"prevention of malformation","subitem_subject_scheme":"Other"},{"subitem_subject":"polypharmacy","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"抗てんかん薬による奇形発現防止に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗てんかん薬による奇形発現防止に関する研究"}]},"item_type_id":"3","owner":"3","path":["559"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-11-09"},"publish_date":"2010-11-09","publish_status":"0","recid":"3407","relation_version_is_last":true,"title":["抗てんかん薬による奇形発現防止に関する研究"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:49:05.672232+00:00"}