{"created":"2023-05-15T09:02:33.416500+00:00","id":3408,"links":{},"metadata":{"_buckets":{"deposit":"e1e67432-efe6-403e-a1a6-32ff896c6f40"},"_deposit":{"created_by":3,"id":"3408","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3408"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003408","sets":["557:558:559"]},"author_link":["9401","9455","9361","9814","9363","9438","9440","9371","9806","9355","9447","9365","9364","9368","9439","9359","9804","9351","9357","9812","9464","9798","9373","9353"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Mechanisms of mood stabilizing effects of antiepileptic drugs. : Differences between acute and chronic effects of antiepileptic drugs on monoaminergic and acetylcholinergic functions.(2nd report)"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"コウテンカンヤク ニヨル ジョウドウ アンテイカ サヨウ ノ ハツゲン キジョ ダイニホウ キュウセイ オヨビ マンセイ トウヨジ ノ シナプス カンゲキナイ デンタツ ブッシツ ドウタイジョウ ノ サイ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1995-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"117","bibliographicPageStart":"107","bibliographicVolumeNumber":"26","bibliographic_titles":[{}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Carbamazepine(CBZ),zonisamide(ZNS),valproate(VPA)の情動安定化作用機序解明の目的で,急性投与時の3剤のmonoamine(MA)遊離に対する効果,急性および慢性投与によるMA,acetylcholine(ACh)代謝に対する用量依存性効果をラット(N=329)を用いて検討した.治療用量のZNS,CBZは細胞外および脳内MA,前駆物質濃度を増加した.過利用量のZNS,CBZはMAおよび前駆物質濃度を低下した.VPAはdopamine(DA)に対してはZNS,CBZと同様の効果を示したが,用量依存性にserotonin(5-HT),前駆物質濃度を増加した. 3剤のAChに対する効果は,治療用量の慢性投与では脳内ACh濃度を増加したが,投与量増加に伴いACh濃度増加作用は減弱し,過剰用量ではACh濃度を低下した.これらの成績から,これらMA(DA,5-HT),ACh濃度増加作用が3剤の情動安定化作用の発現機序の一部を説明しうるものと考えられる.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"精神薬療基金研究年報. 26, 1995, p.107-117","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9355","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カネコ, スナオ"}]},{"nameIdentifiers":[{"nameIdentifier":"9401","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オカダ, モトヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"9804","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ミズノ, カズヒサ"}]},{"nameIdentifiers":[{"nameIdentifier":"9357","nameIdentifierScheme":"WEKO"}],"names":[{"name":"チバ, タケシ"}]},{"nameIdentifiers":[{"nameIdentifier":"9806","nameIdentifierScheme":"WEKO"}],"names":[{"name":"トキナガ, 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