{"created":"2023-05-15T09:02:33.461547+00:00","id":3409,"links":{},"metadata":{"_buckets":{"deposit":"1314a5e6-2026-47ec-88dd-c6e9f4046a7b"},"_deposit":{"created_by":3,"id":"3409","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3409"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003409","sets":["557:558:559"]},"author_link":["9401","9361","9804","9826","9373","9832","9831","9814","9351","9357","9371","9820","9798","9368","9353","9806","9355","9359"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The involvement of adenosinergic function in panic disorder."}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"Adenosine サドウセイ ヤクザイ ニヨル キョウフ ホッサ ハツゲン オヨビ ソノ ヨクセイ キジョ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"94","bibliographicPageStart":"88","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"精神薬療基金研究年報"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Adenosine(AD)受容体(R)非特異的阻害薬(ant)caffeine(CF)の恐怖発作(PA)誘発作用,及びcarbamazepine(CBZ)のPA抑制効果機序解明のためmicrodialysisを用い,線条体dopamine(DA)遊離に対するA1-R,A2-Rの効果を検討し,続いてCF,CBZ両剤のAD-Rに対する効果を詳細に検討した.非特異的AD-R作動薬(ago) AD(50μM),選択的A1-R-ago CCPA(1μM)はDA遊離を抑制し,非特異的AD-R-antCF(100μM),選択的A1-R-antCPT(50μM)はDA遊離を増加した.しかし,A2-R-agoDPMA(5μM),A2a-R-agoCGS21680(10μM),A2-R-antDMPX (10μM)はDA遊離に効果を示さなかった.一方,CPT pretreatment群では,AD,DPMAはDA遊離を増加,CF,DMPXは減少,CGS21680は効果を示さなかった.CBZ(100μM)はDA遊離を単独,CPTpretreatmentの両群で増加した.A1-R機能亢進はDA遊離を抑制し,逆にA1-R機能抑制の環境下でA2-R機能亢進はDA遊離を増加した.A2a-R-agoのCGS21680は遊離を変化しなかったことから,A2b-R機能亢進,あるいはA2a-RとA2b-R両受容体機能亢進がDA遊離を増加するものと考えられる.以上よりCFはAl/A2(A2b)-R-ant,CBZはA1-R-ant,A2(A2b)-R-agoである可能性が示唆された.CFはPAを誘発,CBZはPAを抑制することから,A2-R(A2b-R)機能抑制がPA誘発,A2-R(A2b-R)機能亢進がPA抑制に関与する可能性が示唆された.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"精神薬療基金研究年報. 27, 1996, p.88-94","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9355","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カネコ, スナオ"}]},{"nameIdentifiers":[{"nameIdentifier":"9401","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オカダ, モトヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"9804","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ミズノ, 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