{"created":"2023-05-15T09:02:33.508302+00:00","id":3410,"links":{},"metadata":{"_buckets":{"deposit":"a6d0f505-ca7d-4dec-a5d1-dfd347f02b1e"},"_deposit":{"created_by":3,"id":"3410","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3410"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003410","sets":["557:558:559"]},"author_link":["9401","9369","9356","9849","9372","9361","9826","9371","9820","9375","9355","9352","9844","9856","9859","9374","9368","9850","9359","9360","9804","9832","9351","9357","9370","9373","9353"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Effects of Ca²⁺channel antagonists on striatal dopamine and DOPA releases，studied by in vivo microdialysis."}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"シンケイ デンタツ ブッシツ ユウリ キコウ ニ タイスル デンイ イゾンショウ Ca²⁺channel subtype ノ キノウ センジョウタイ dopamin ト DOPA ユウリ オ シヒョウ ニシタ ケントウ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1998-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"126","bibliographicPageStart":"116","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"精神薬療基金研究年報"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"線条体dopamine，3，4-dihydroxyphenylalanine(DOPA)遊離に対する電位依存性Ca²⁺channel subtypeの機能を検討する目的で，線条体dopamine，DOPAの基礎遊離，Ca²⁺及びK⁺依存性遊離に対する，N- ，P-， Q-type Ca²⁺channel antagonist，ω-conotoxin GVIA(GVIA)，ω-agatoxin IVA(IVA)，ω-conotoxin MVIIC(MVIIC)の効果をin vivo microdialysisを用いて検討した.線条体dopamine，DOPAの基礎遊離， Ca²⁺依存性遊離はN-type Ca²⁺channelにより規定されており，K⁺依存性dopamine，DOPA遊離はP/Q-typeCa²⁺channelにより規定されていた.しかし，DOPAの基礎遊離，Ca²⁺依存性遊離のN-type Ca²⁺channelの感受性はdopamineよりも低く，逆にK⁺依存性DOPA遊離のP/Q-type Ca²⁺channelに対する感受性はdopamineよりも高かった.以上の結果から線条体DOPA遊離は神経伝達物質様であり，しかもdopamineとは異なる遊離機序を有している可能性が示唆された.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"精神薬療基金研究年報. 29, 1998, p.116-126","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9355","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カネコ, スナオ"}]},{"nameIdentifiers":[{"nameIdentifier":"9401","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オカダ, モトヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"9844","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カワタ, ユウコ"}]},{"nameIdentifiers":[{"nameIdentifier":"9357","nameIdentifierScheme":"WEKO"}],"names":[{"name":"チバ, タケシ"}]},{"nameIdentifiers":[{"nameIdentifier":"9826","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オオギヤ, 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