{"created":"2023-05-15T09:02:33.602159+00:00","id":3412,"links":{},"metadata":{"_buckets":{"deposit":"18810b2c-ced2-4dff-93df-34964826ed08"},"_deposit":{"created_by":3,"id":"3412","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3412"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003412","sets":["557:558:559"]},"author_link":["9401","9866","9369","9861","9884","9892","9363","9355","9879","9365","9364","9844","9427","9374","9368","9885","9359","9351","9872","9373","9423"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Effects of dopamine precursor,L-DOPA, on mechanisms of neurotransmitter release"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"Dopamine ゼンク ブッシツ L-DOPA ノ シンケイ デンタツケイ キノウ シュウショク サヨウ ノ ケントウ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"235","bibliographicPageStart":"228","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"精神薬療研究年報"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Dopamine(DA)の前駆物質L-3,4-dihydroxyphenylalanine(L-DOPA)\nの神経伝達物質遊離機構に対する機能解明を目的に,in vivo microdialysisを用いてDA,serotonin (5-HT),acetylcholine(ACh)遊離に対する,細胞外DOPA濃度依存性効果を検討した.同時にmaximal electroshock seizure(MES)を用いたけい\nれん閾値に対するL-DOPAの効果も検討した.細胞外DOPA濃度が100nM以下では濃度依存性にDA,5-HT,ACh遊離を亢進したが,100nM以上では逆にDA,5-HT,ACh遊離を抑制した.同様にDA,5-HT,ACh遊離亢進作用を有する100nM以下の細胞外DOPA濃度ではMESを軽度抑制し,100nM以上ではMESを亢進した.以上の結果は,L-DOPAの神経伝達物質あるいは神経修飾物質様作用の存在を示唆するものである.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"精神薬療研究年報. 32, 2000, p.228-235","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9401","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オカダ, モトヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"9866","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ムラカミ, タクヤ"}]},{"nameIdentifiers":[{"nameIdentifier":"9884","nameIdentifierScheme":"WEKO"}],"names":[{"name":"シュ, ゴウ"}]},{"nameIdentifiers":[{"nameIdentifier":"9885","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カマタ, 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Yuko"}]},{"nameIdentifiers":[{"nameIdentifier":"9365","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kondo, Tsuyoshi"}]},{"nameIdentifiers":[{"nameIdentifier":"9359","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kaneko, Sunao"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"先進医薬研究振興財団"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_rights_14":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"本文データは財団法人先進医薬研究振興財団の許諾に基づき複製したものである。"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11453283","subitem_source_identifier_type":"NCID"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.7","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前大学医学部神経精神医学講座"},{"subitem_text_value":"弘前大学医学部神経精神医学講座"},{"subitem_text_value":"弘前大学医学部神経精神医学講座"},{"subitem_text_value":"弘前大学医学部神経精神医学講座"},{"subitem_text_value":"弘前大学医学部神経精神医学講座"},{"subitem_text_value":"弘前大学医学部神経精神医学講座"},{"subitem_text_value":"弘前大学医学部神経精神医学講座"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡田, 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