{"created":"2023-05-15T09:02:33.647097+00:00","id":3413,"links":{},"metadata":{"_buckets":{"deposit":"c05c666e-20cf-406e-8b3f-84076315539e"},"_deposit":{"created_by":3,"id":"3413","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3413"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003413","sets":["557:558:559"]},"author_link":["9401","9866","9374","9879","9373","9884","9369","9892","9351","9844","9872","9427","9368","9423","9861","9355","9885","9359"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Two functional complexes for exocytosis of hippocampal serotonin"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"カイコウ ブンピツ キコウ ニオケル シナップス タンパク ト デンイ イゾンセイ カルシウム チャネル キノウテキ フクゴウタイ ノ カイセキ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"37","bibliographicPageStart":"28","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"精神薬療研究年報"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"神経伝達物質の開口分泌機構解明を目的に,ラット海馬セロトニン(5-HT)遊離に対する電位依存性カルシウムチャネル(VSCC),蛋白リン酸化酵素(PK),シナップス蛋白(SNARE)の相互作用をmicrodialysisを用いて検討した.5-HT基礎遊離はN型VSCC･PKC･syntaxin,P型VSCC･PKA･synaptobrevin各阻害薬により濃度依存性に抑制された.Ca²⁺刺激性遊離はN型VSCC･PKC･syntaxin阻害薬により濃度依存性に抑制されたが,P型VSCC･PKA･synaptobrevin阻害薬は効果がなかった.K⁺刺激性遊離はN型VSCC･PKC･syntaxin及びP型VSCC･PKA･synaptobrevin阻害薬により抑制された.相互作用を検討した結果,基礎遊離はN型VSCC/PKC/syntaxinとP型VSCC/PKA/synaptobrevinの機能的複合体により規定されていたが,N型VSCC/PKC/syntaxinが優位であった.Ca²⁺刺激性遊離はN型VSCC/PKC/syntaxinにより規定されP型VSCC/PKA/synaptobrevin非感受性であった.K⁺刺激性遊離はN型VSCC/PKC/syntaxinとP型VSCC/PKA/synaptobrevinの機能的複合体により規定されていたが,その感受性はP型VSCC/PKA/synaptobrevinが有意に高かった.以上の結果は,PKC活性亢進を介したN型VSCCとsyntaxinの相互作用と,PKAを介したP型VSCCとsynaptobrevinの相互作用により5HT遊離が規定されていることを示している.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"精神薬療研究年報. 33, 2001, p.28-37","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9401","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オカダ, モトヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"9355","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カネコ, スナオ"}]},{"nameIdentifiers":[{"nameIdentifier":"9866","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ムラカミ, タクヤ"}]},{"nameIdentifiers":[{"nameIdentifier":"9884","nameIdentifierScheme":"WEKO"}],"names":[{"name":"シュ, ゴウ"}]},{"nameIdentifiers":[{"nameIdentifier":"9885","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カマタ, アキヒサ"}]},{"nameIdentifiers":[{"nameIdentifier":"9844","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カワタ, ユウコ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9373","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Okada, Motohiro"}]},{"nameIdentifiers":[{"nameIdentifier":"9359","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kaneko, Sunao"}]},{"nameIdentifiers":[{"nameIdentifier":"9872","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Murakami, Takuya"}]},{"nameIdentifiers":[{"nameIdentifier":"9427","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Zhu, Gang"}]},{"nameIdentifiers":[{"nameIdentifier":"9892","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kamata, Akihisa"}]},{"nameIdentifiers":[{"nameIdentifier":"9374","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kawata, Yuko"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"先進医薬研究振興財団"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_rights_14":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"本文データは財団法人先進医薬研究振興財団の許諾に基づき複製したものである。"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11453283","subitem_source_identifier_type":"NCID"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.7","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前大学医学部神経精神医学講座"},{"subitem_text_value":"弘前大学医学部神経精神医学講座"},{"subitem_text_value":"弘前大学医学部神経精神医学講座"},{"subitem_text_value":"弘前大学医学部神経精神医学講座"},{"subitem_text_value":"弘前大学医学部神経精神医学講座"},{"subitem_text_value":"弘前大学医学部神経精神医学講座"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡田, 元宏"}],"nameIdentifiers":[{"nameIdentifier":"9368","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"兼子, 直"}],"nameIdentifiers":[{"nameIdentifier":"9351","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村上, 拓也"}],"nameIdentifiers":[{"nameIdentifier":"9861","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"朱, 剛"}],"nameIdentifiers":[{"nameIdentifier":"9423","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鎌田, 晃寿"}],"nameIdentifiers":[{"nameIdentifier":"9879","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"河田, 祐子"}],"nameIdentifiers":[{"nameIdentifier":"9369","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"SeishinYakuryoNenpo_33_28.pdf","filesize":[{"value":"594.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"SeishinYakuryoNenpo_33_28.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3413/files/SeishinYakuryoNenpo_33_28.pdf"},"version_id":"0eeab8cc-d156-4be5-8ffd-11446ef21d43"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"serotonin","subitem_subject_scheme":"Other"},{"subitem_subject":"microdialysis","subitem_subject_scheme":"Other"},{"subitem_subject":"voltage-sensitiveCa2⁺channel","subitem_subject_scheme":"Other"},{"subitem_subject":"protein kinase","subitem_subject_scheme":"Other"},{"subitem_subject":"SNARE","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"開口分泌機構におけるシナップス蛋白と電位依存性カルシウムチャネル機能的複合体の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"開口分泌機構におけるシナップス蛋白と電位依存性カルシウムチャネル機能的複合体の解析"}]},"item_type_id":"3","owner":"3","path":["559"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-11-11"},"publish_date":"2010-11-11","publish_status":"0","recid":"3413","relation_version_is_last":true,"title":["開口分泌機構におけるシナップス蛋白と電位依存性カルシウムチャネル機能的複合体の解析"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:20:54.136231+00:00"}