{"created":"2023-05-15T09:02:33.782943+00:00","id":3416,"links":{},"metadata":{"_buckets":{"deposit":"8943ac03-c703-4794-a04f-3a36675c9683"},"_deposit":{"created_by":3,"id":"3416","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3416"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003416","sets":["557:558:559"]},"author_link":["9806","9814","9798"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Effects of Antiepileptic Drugs on Epoxide Hydrolase and Glutathione S-transferase Activities"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"コウテンカンヤク ノ epoxide hydrolase オヨビ glutathione S-transferase カッセイ ニ タイスル サヨウ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"171","bibliographicPageStart":"165","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"てんかん研究"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"抗てんかん薬(antiepileptic drugs:AED)の催奇性の機序解明の一環として、胎児毒性との関連が指摘されているepoxide体の加水分解酵素epoxide hydrolase(EH)および抱合酵素glutathione S-transferase(GST)の両酵素活性に与えるcarbamazepine(CBZ)、phenobarbital(PB)、phenytoin(PHT)、valproic acid(VPA)、zonisamide(ZNS)の影響を検討した。ラット肝マイクロゾームを用いて両酵素の活性を各AEDの影響下で対照群と比較検討したところ、VPAはEHおよびGST(2-2、4-4、7-7)活性を治療濃度(50～100μg/ml)より濃度依存性に抑制し、CBZ(10μg/ml)およびPB(40μg/ml)は治療濃度よりGST7-7活性を有意に抑制した。一方、PHTおよびZNSはEH、GSTの両酵素活性に対し治療濃度では影響を与えなかった。以上の結果から、VPA、CBZおよびPBを含む多剤併用時の奇形発現の増加の一因として、これらの薬剤によるepoxide解毒機構の低下が関与する可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"てんかん研究. 15(3), 1997, p.165-171","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9806","nameIdentifierScheme":"WEKO"}],"names":[{"name":"トキナガ, ノボル"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9814","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tokinaga, 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昇"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"TenkanKenkyu_15(3)_165.pdf","filesize":[{"value":"591.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"TenkanKenkyu_15(3)_165.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3416/files/TenkanKenkyu_15(3)_165.pdf"},"version_id":"8f5ce938-ac14-463c-b562-1cbd18a2c873"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"antiepileptic drug","subitem_subject_scheme":"Other"},{"subitem_subject":"teratogenicity","subitem_subject_scheme":"Other"},{"subitem_subject":"epoxide","subitem_subject_scheme":"Other"},{"subitem_subject":"epoxide hydrolase","subitem_subject_scheme":"Other"},{"subitem_subject":"glutathione S-transferase","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"抗てんかん薬のepoxide hydrolaseおよびglutathione S-transferase活性に対する作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗てんかん薬のepoxide hydrolaseおよびglutathione S-transferase活性に対する作用"}]},"item_type_id":"3","owner":"3","path":["559"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-11-12"},"publish_date":"2010-11-12","publish_status":"0","recid":"3416","relation_version_is_last":true,"title":["抗てんかん薬のepoxide hydrolaseおよびglutathione S-transferase活性に対する作用"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:10:46.859525+00:00"}