{"created":"2023-05-15T09:02:39.055958+00:00","id":3513,"links":{},"metadata":{"_buckets":{"deposit":"669c57f7-7b2a-4c8e-906c-01f22898a7af"},"_deposit":{"created_by":3,"id":"3513","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3513"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003513","sets":["557:561:601"]},"author_link":["10443","10442","10441"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"A Study on Diurnal Variation of Serum Level of Antiepileptic Drugs: Clinical Significance of Measurement of Diurnal Variation"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1983-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"471","bibliographicPageStart":"465","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"入院治療中のてんかん患者19名を対象に,血清抗てんかん剤濃度の日内変動を調べた.血清抗てんか\nん剤(Phenytoin(PHT),Carbamazepine(CBZ),Phenobarbital(PB))の日内変動のパターンと最低\n及び最高血清濃度(Cmin,Cmax)を生じる時間と日内変動の大きさを検討した.ついで診療時間における\n外来患者の血清濃度を入院患者の血清濃度の日内変動と比較検討した. 血清濃度の測定には酵素免疫法を用\nいた.① 日内変動のパターンはPHT,PBでは変動の小さな平坦なパターンを示す.一方CBZでは変動が\n大きく,個々の症例で異なったパターンを示す.②PHT,CBZでは血清濃度は早朝第1回目服薬前にCmin\nを示し,6時間から8時間後にCmaxを示す.PBではCmin,Cmaxの出現時間はかなり変動する.③\n外来患者では,診療時間における血清濃度はCmin,Cmaxの間にあり,PHT の場合は変動が小さいため\nにCminに近い値を示す.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 35(3), 1983, p.465‐471","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"10442","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ホンマ, ヒロアキ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"10443","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Homma, Hiroaki"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学医学部"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前大学医学部神経精神医学教室"},{"subitem_text_value":"Department of Neuropsychiatry, Hirosaki University School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"本間, 博彰"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_35_3_465.pdf","filesize":[{"value":"418.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_35_3_465.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3513/files/HirosakiMedJ_35_3_465.pdf"},"version_id":"597b3653-9116-4d85-9a56-ec1b1a020d7a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"diurnal variation","subitem_subject_scheme":"Other"},{"subitem_subject":"antiepileptic drug","subitem_subject_scheme":"Other"},{"subitem_subject":"serum level","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"血清抗てんかん剤の日内変動 : その測定の臨床上の意義","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"血清抗てんかん剤の日内変動 : その測定の臨床上の意義"}]},"item_type_id":"3","owner":"3","path":["601"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-02-27"},"publish_date":"2009-02-27","publish_status":"0","recid":"3513","relation_version_is_last":true,"title":["血清抗てんかん剤の日内変動 : その測定の臨床上の意義"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T06:43:29.991679+00:00"}