{"created":"2023-05-15T09:02:39.475171+00:00","id":3522,"links":{},"metadata":{"_buckets":{"deposit":"ad251f69-8368-4524-a5f1-86e1cb765ff4"},"_deposit":{"created_by":3,"id":"3522","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3522"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003522","sets":["557:561:607"]},"author_link":["9355","9351"],"item_5_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"てんかん, 妊娠, 抗てんかん薬"}]},"item_5_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"テンカン ニンシン コウテンカンヤク"}]},"item_5_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1986-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"456","bibliographicPageStart":"434","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_5_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Clinical and basic researches on epilepsy and pregnancy. in particular of antiepileptic\ndrugs (AEDs) on the fetus and the epileptic mother, and those of pregnancy on the course of\nepilepsy were reviewed.\nThe complete control of seizures in the pregestational period and regular drug taking are very\nimportant for better management of pregnant epileptics with medication, since the seizure frequency\nremains mostly unchanged when the patient's compliance is good. If the serum level\ndecreases, one must confirm the patient's compliance. Once compliance has been established, the\ndose should be increased only when seizures occur.\nMost AEDs cross the placenta and some cause unwanted effects on the embryo, the fetus, or\nthe newborn.\nThus pre-conceptional counselling should ensure that an epileptic embarks upon a pregnancy\nwith her epilepsy well controlled by a minimal dose of AEDs, and adequate answers for the questions\nraised by the patient should be given to prevent poor compliance.\nThere is an increased risk of major congenital malformations among the offsprings of women\nwith epilepsy, most of whom are on AEDs. Part of this increase is due to exposure to AEDs.\nOther factors also appear to play an important role. Prevention of malformation can take place\nbefore the onset of the pregnancy by decreasing the dose of the drug and/or changing from a\ncombination of AEDs to a single drug, since there is a dose-response relation for teratogenesis\nand a greater occurrence of congenital malformation when the mother receives combined AED\ntherapy.\nAn aspect of prenatal growth deficiency that has raised concern is that brain growth may be\naffected, producing microcephaly and mild to moderate mental retardation. However, the delay\nin the physical development of the offspring may be transient. The psychomotor retardation\ncontinued only through infancy. if they were nursed properly.","subitem_description_type":"Abstract"}]},"item_5_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 38(3), 1986, p.434-456","subitem_description_type":"Other"}]},"item_5_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9355","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カネコ, スナオ"}]}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9351","nameIdentifierScheme":"WEKO"}],"names":[{"name":"兼子, 直"}]}]},"item_5_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学医学部"}]},"item_5_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_5_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_5_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_5_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.7","subitem_subject_scheme":"NDC"}]},"item_5_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_5_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Neuropsychiatry, Hirosaki University, School of Medicine"}]},"item_5_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kaneko, Sunao"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_38(3)_434.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_38(3)_434.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3522/files/HirosakiMedJ_38(3)_434.pdf"},"version_id":"7aca23f2-6f7b-4552-b101-b0f6dbf61dc2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"malformation","subitem_subject_scheme":"Other"},{"subitem_subject":"seizure frequency","subitem_subject_scheme":"Other"},{"subitem_subject":"compliance","subitem_subject_scheme":"Other"},{"subitem_subject":"hormone","subitem_subject_scheme":"Other"},{"subitem_subject":"folic acid","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Epilepsy, Pregnancy and Antiepileptic Drugs","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Epilepsy, Pregnancy and Antiepileptic Drugs"}]},"item_type_id":"5","owner":"3","path":["607"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-07-17"},"publish_date":"2009-07-17","publish_status":"0","recid":"3522","relation_version_is_last":true,"title":["Epilepsy, Pregnancy and Antiepileptic Drugs"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T06:43:29.654336+00:00"}