{"created":"2023-05-15T09:02:39.517868+00:00","id":3523,"links":{},"metadata":{"_buckets":{"deposit":"e06fffd7-23e7-4382-a42a-2d9b85dba5be"},"_deposit":{"created_by":3,"id":"3523","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3523"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003523","sets":["557:561:608"]},"author_link":["10569","10571","10570"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Streotyped Behavior and Hypersensitive Behavioral Responce (Reverse Tolerance Phenomenon) Induced by Methamphetamine Administration in Combination with Scopolamine"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1987-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"466","bibliographicPageStart":"447","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"妄想型分裂病の生物学的病態には線条体,中脳辺縁領域dopamine(DA)系と,これに対する抑制\n系との機能関連の破綻および前頭葉皮質DA系機能の変化が関与する可能性をWistar系雄ラットを用い\n行動薬理学的に検証した.抑制系としてコリン作動系を取りあげ,methamphetamine(MAP)とscopol\namine(SCOP)を併用して反復投与することによる線条体,中脳辺縁領域DA系の過剰活動とコリン作動\n系の機能低下の共存下での常同行動,逆耐性現象を従来のMAP反復投与モデルと比較,検討した.また,\nMAP+SCOP投与群の常同行動,逆耐性現象について,mesocortico-prefrontalDA 系の機能低下を来す\nとされる隔離飼育ラットと集団飼育ラットに分けて検討した.MAP+SCOP投与群はMAP投与群に比\nし,また,隔離飼育群は集団飼育群に比し,常同行動,逆耐性現象が顕著であり,安定した出現様態を保\nち,かつDA受容体遮断薬の作用を受け難かった.したがって,上記の可能性は支持され得ると考えた.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 39(3), 1987, p.447‐466","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"10570","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ユイ, クニオ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"10571","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yui, Kunio"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学医学部"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前大学医学部神経精神医学教室"},{"subitem_text_value":"Department of Neuropsychiatry, Hirosaki University School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"油井, 邦雄"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_39(3)_447.pdf","filesize":[{"value":"1.1 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スコポラミン同時投与による常同行動と行動上の過敏反応(逆耐性現象)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"メトアンフェタミン, スコポラミン同時投与による常同行動と行動上の過敏反応(逆耐性現象)"}]},"item_type_id":"3","owner":"3","path":["608"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-02-27"},"publish_date":"2009-02-27","publish_status":"0","recid":"3523","relation_version_is_last":true,"title":["メトアンフェタミン, スコポラミン同時投与による常同行動と行動上の過敏反応(逆耐性現象)"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T06:43:27.234678+00:00"}