@article{oai:hirosaki.repo.nii.ac.jp:00003549,
 author = {Mariya, Yasushi and Streffer, Christian and Zolzer, Friedo and Abe, Yoshinao},
 issue = {1},
 journal = {弘前医学},
 month = {Aug},
 note = {The in vitro combined effects of irradiation and SN－38, an active metabolite of irinotecan, on the human squamous cell carcinoma cell line PECA4197 derived from a head and neck carcinoma were examined．Exponentially growing cell cultures were pretreated with SN-38 for 90 min, in the concentration of 0.005 and 0.5μg/ml, respectively，and then irradiated. As a control, cells without pretreatment were also irradiated. The cell survival rate was determined using a conventional clonogenic survival assay. The enhanced effects of radiation-induced cell killing, depending upon the concentration of SN-38, were presented with a decrease of shoulder part or extrapolation number (n) of survival curve, corrected for the cytotoxicity of SN-38 alone. The value of D0 was unchanged after SN-38 pretreatment. These results suggested that the pretreatment with SN-38 inhibited potentially lethal damage repair in the cell line, leading to the potentiation of irradiation effects．, 弘前医学. 51(1), 1999, p.10-14},
 pages = {10--14},
 title = {Combined Treatment Effects of Irradiation and SN－38, an Active Metabolite of Camptothecin Derivative Irinotecan, on the Human Tumor Cell Line PECA 4197},
 volume = {51},
 year = {1999}
}