{"created":"2023-05-15T09:02:41.066492+00:00","id":3549,"links":{},"metadata":{"_buckets":{"deposit":"6eb9eff8-3bd9-4834-9be2-2d8a632f20cb"},"_deposit":{"created_by":3,"id":"3549","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3549"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003549","sets":["557:561:627"]},"author_link":["10544","10780","10812","10805","10789","10562","10771","10553"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ヒト腫瘍培養細胞株PECA4197に対する放射線およびSN－38（カンプトテシン誘導体イリノテカン活性代謝物）併用効果"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ヒト シュヨウ バイヨウ サイボウカブ PECA4197 ニ タイスル ホウシャセン オヨビ SN-38 カンプトテシン ユウドウタイ イリノテカン カッセイ タイシャブツ ヘイヨウ コウカ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-08-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"14","bibliographicPageStart":"10","bibliographicVolumeNumber":"51","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The in vitro combined effects of irradiation and SN－38, an active metabolite of irinotecan, on the human squamous cell carcinoma cell line PECA4197 derived from a head and neck carcinoma were examined．Exponentially growing cell cultures were pretreated with SN-38 for 90 min, in the concentration of 0.005 and 0.5μg/ml, respectively，and then irradiated. As a control, cells without pretreatment were also irradiated. The cell survival rate was determined using a conventional clonogenic survival assay. The enhanced effects of radiation-induced cell killing, depending upon the concentration of SN-38, were presented with a decrease of shoulder part or extrapolation number (n) of survival curve, corrected for the cytotoxicity of SN-38 alone. The value of D0 was unchanged after SN-38 pretreatment. These results suggested that the pretreatment with SN-38 inhibited potentially lethal damage repair in the cell line, leading to the potentiation of irradiation effects．","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 51(1), 1999, p.10-14","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"10553","nameIdentifierScheme":"WEKO"}],"names":[{"name":"マリヤ, ヤスシ"}]},{"nameIdentifiers":[{"nameIdentifier":"10789","nameIdentifierScheme":"WEKO"}],"names":[{"name":"アベ, ヨシナオ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"10544","nameIdentifierScheme":"WEKO"}],"names":[{"name":"真里谷, 靖"}]},{"nameIdentifiers":[{"nameIdentifier":"10771","nameIdentifierScheme":"WEKO"}],"names":[{"name":"阿部, 由直"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学医学部・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"494.54","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"外科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Radiology，Hirosaki University School of Medicine"},{"subitem_text_value":"Institut ftir Medizinische Strahlenbiologie，Universitats-klinikum Essen"},{"subitem_text_value":"弘前大学医学部放射線医学講座"},{"subitem_text_value":"ドイツ・エッセン大学医学放射線生物学研究所"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mariya, Yasushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Streffer, Christian"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Zolzer, Friedo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Abe, Yoshinao"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_51_10.pdf","filesize":[{"value":"505.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_51_10.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3549/files/HirosakiMedJ_51_10.pdf"},"version_id":"e5f75479-6181-40b7-817d-9df6dffba1a0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"SN-38","subitem_subject_scheme":"Other"},{"subitem_subject":"irinotecan","subitem_subject_scheme":"Other"},{"subitem_subject":"irradiation","subitem_subject_scheme":"Other"},{"subitem_subject":"inhibitionofPLDR","subitem_subject_scheme":"Other"},{"subitem_subject":"Clonogenicsurvivalassay","subitem_subject_scheme":"Other"},{"subitem_subject":"イリノテカン","subitem_subject_scheme":"Other"},{"subitem_subject":"放射線照射","subitem_subject_scheme":"Other"},{"subitem_subject":"潜在的致死損傷からの回復阻害","subitem_subject_scheme":"Other"},{"subitem_subject":"コロニー法","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Combined Treatment Effects of Irradiation and SN－38, an Active Metabolite of Camptothecin Derivative Irinotecan, on the Human Tumor Cell Line PECA 4197","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Combined Treatment Effects of Irradiation and SN－38, an Active Metabolite of Camptothecin Derivative Irinotecan, on the Human Tumor Cell Line PECA 4197"}]},"item_type_id":"3","owner":"3","path":["627"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-10-18"},"publish_date":"2013-10-18","publish_status":"0","recid":"3549","relation_version_is_last":true,"title":["Combined Treatment Effects of Irradiation and SN－38, an Active Metabolite of Camptothecin Derivative Irinotecan, on the Human Tumor Cell Line PECA 4197"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:03:03.365088+00:00"}