{"created":"2023-05-15T09:02:41.867214+00:00","id":3561,"links":{},"metadata":{"_buckets":{"deposit":"56dbd4d2-5c72-4e17-af34-a89cf5e4680a"},"_deposit":{"created_by":3,"id":"3561","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3561"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003561","sets":["557:561:631"]},"author_link":["10544","10926","10834","10772","10780","10845","10856","10781","10789","10779","10788","10920","10764","10916","10770","10562","10771","10553"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Comet Assay as a Predictive Assay for Radiosensitivity of Two Human Brain Tumor Cell Lines"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ヒト ノウシュウヨウ サイボウ オ モチイタ comet assay ホウ ニ ヨル ホウシャセン カンジュセイ シケン"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3/4","bibliographicPageEnd":"118","bibliographicPageStart":"110","bibliographicVolumeNumber":"52","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"放射線感受性試験として微小核形成法とcomet assay法はそれぞれ独立に検討されたが，これらの試験法について比較検討した報告はない。本研究では，二種類のヒト脳腫瘍細胞（星細胞腫由来Beckerと髄芽腫由来ONS76）を用い，標準的な放射線感受性をコロニー法で検定し，この結果を基に微小核形成法とcomet assay法について比較検討した。コロニー法では，BeckerはONS76に比較して放射線抵抗性であった。微小核形成法ではBeckerとONS76の感受性の差を検出できなかった。一方，comet assay法ではBeckerがONS76に比較してDNA損傷の程度がより小さく，その修復もより迅速であり，これらはコロニー法の結果と合致した。この結果，comet assay法は微小核形成法よりも放射線感受性を正確に反映し，かつ簡便・迅速な検査法として優れており，臨床的有用性が期待された。","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 51(3/4), 2001, p.110-118","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"10845","nameIdentifierScheme":"WEKO"}],"names":[{"name":"コンドウ, ヒデヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"10920","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オオハタ, タカシ"}]},{"nameIdentifiers":[{"nameIdentifier":"10788","nameIdentifierScheme":"WEKO"}],"names":[{"name":"アボ, ミツル"}]},{"nameIdentifiers":[{"nameIdentifier":"10781","nameIdentifierScheme":"WEKO"}],"names":[{"name":"アオキ, マサヒコ"}]},{"nameIdentifiers":[{"nameIdentifier":"10553","nameIdentifierScheme":"WEKO"}],"names":[{"name":"マリヤ, ヤスシ"}]},{"nameIdentifiers":[{"nameIdentifier":"10789","nameIdentifierScheme":"WEKO"}],"names":[{"name":"アベ, ヨシナオ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"10834","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kondo, Hidehiro"}]},{"nameIdentifiers":[{"nameIdentifier":"10926","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ohata, Takashi"}]},{"nameIdentifiers":[{"nameIdentifier":"10779","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Abo, Mitsuru"}]},{"nameIdentifiers":[{"nameIdentifier":"10772","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"476","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/476_ja.html"}],"names":[{"name":"Aoki, Masahiko"}]},{"nameIdentifiers":[{"nameIdentifier":"10562","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Mariya, Yasushi"}]},{"nameIdentifiers":[{"nameIdentifier":"10780","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Abe, Yoshinao"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学医学部・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"494.54","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"外科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前大学医学部放射線医学講座"},{"subitem_text_value":"青森市民病院放射線科"},{"subitem_text_value":"Department of Radiology，Hirosaki University, School of Medicine"},{"subitem_text_value":"Radiology，Aomori City Hospital"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"近藤, 英宏"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大畑, 崇"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"阿保, 満"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"青木, 昌彦"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"真里谷, 靖"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"阿部, 由直"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_52_110.pdf","filesize":[{"value":"941.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_52_110.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3561/files/HirosakiMedJ_52_110.pdf"},"version_id":"a9b6b830-3ced-4957-b2be-c4145f8b6c19"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"コロニー形成法","subitem_subject_scheme":"Other"},{"subitem_subject":"comet assay法","subitem_subject_scheme":"Other"},{"subitem_subject":"微小核形成法","subitem_subject_scheme":"Other"},{"subitem_subject":"放射線感受性試験","subitem_subject_scheme":"Other"},{"subitem_subject":"colony method","subitem_subject_scheme":"Other"},{"subitem_subject":"comet assay","subitem_subject_scheme":"Other"},{"subitem_subject":"micronucleus assay","subitem_subject_scheme":"Other"},{"subitem_subject":"radiosensitivity predictive assay","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ヒト脳腫瘍細胞を用いたcomet assay法による放射線感受性試験","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト脳腫瘍細胞を用いたcomet assay法による放射線感受性試験"}]},"item_type_id":"3","owner":"3","path":["631"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-10-18"},"publish_date":"2013-10-18","publish_status":"0","recid":"3561","relation_version_is_last":true,"title":["ヒト脳腫瘍細胞を用いたcomet assay法による放射線感受性試験"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:53:10.865427+00:00"}