{"created":"2023-05-15T09:02:42.133064+00:00","id":3565,"links":{},"metadata":{"_buckets":{"deposit":"e6f650eb-7c95-46ad-9ce3-e44abe27ced8"},"_deposit":{"created_by":3,"id":"3565","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3565"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003565","sets":["557:561:633"]},"author_link":["10994","11003","10950","10037","11005","10993","10960","10997","10955","10991","12840","10999","10036","10995","12852","11000","10988","10035"],"item_5_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"CYP2C19 Mutation Frequency in Elderly Subjects Living In a Sparsely Populated Area of Shimokita Peninsula"}]},"item_5_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"シモキタ ハントウ カソチイキ ザイジュウ コウレイシャ ニオケル CYP2C19 イデンシ ヘンイヒンド ノ ケントウ"}]},"item_5_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-08-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"22","bibliographicPageStart":"18","bibliographicVolumeNumber":"55","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_5_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"内因性や外因性物質の酸化代謝を担うチトクロームP450(CYP)は複数の酵素からなる酵素群であり,その分子種である2C19(CYP2C19)はdiazepamやomeprazoleなど多くの薬物の代謝酵素として知られる.生体内CYP2C19活性には遺伝的多塑性があり,日本人の酵素活性欠損者はCYP2C19もしくは*3の変異遺伝子を有する.これまでの青森地域のABO式血液型の頻度分布や東北地方出身者におけるCYP2C19PMの頻度を検討した報告では青森県出身者と他地域出身者においてCYP2C19PMの頻度や変異遺伝子頻度が異なる可能性を示唆している.そこで今回下北半島の過疎地である川内町在住高齢者のCYP2C19変異遺伝子の頻度を検討し,これまでの日本人の報告と比較した.川内町出身の在住者108名を対象にCYP2C19変異遺伝子を検索した.今回得られた遺伝子型頻度はhomoEM:32.4%,hetEM:51.9%,PM:15.7%および変異遺伝子アリル頻度は*1:58.3%,*2:30.6%,*3:11.1%とこれまでの日本人の報告と有意の差を認めなかった.本研究の結果やこれまでの報告から,日本人においては出身地域によるCYP2C19変異遺伝子の頻度や遺伝子型頻度の差異は小さいと考えられた.","subitem_description_type":"Abstract"}]},"item_5_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 55(1), 2003, 18-22","subitem_description_type":"Other"}]},"item_5_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"10994","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イシザワ, ユキオ"}]},{"nameIdentifiers":[{"nameIdentifier":"10995","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タカハタ, タケノリ"}]},{"nameIdentifiers":[{"nameIdentifier":"10036","nameIdentifierScheme":"WEKO"}],"names":[{"name":"フルコオリ, ノリオ"}]},{"nameIdentifiers":[{"nameIdentifier":"10997","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サイトウ, マサト"}]},{"nameIdentifiers":[{"nameIdentifier":"10955","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ササキ, ムツオ"}]},{"nameIdentifiers":[{"nameIdentifier":"10999","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タテイシ, トモナリ"}]}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11000","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ishizawa, 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