{"created":"2023-05-15T09:02:42.515648+00:00","id":3573,"links":{},"metadata":{"_buckets":{"deposit":"6b2b09b1-fe11-46e6-b5a3-3ebe3fc63573"},"_deposit":{"created_by":3,"id":"3573","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3573"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003573","sets":["557:561:635"]},"author_link":["11135","11114","11126","11138","11118","11120","11113","11119","11116","11123","11134","11130","11128","11121","11131","11133","11132","11136","11122","11117","11125","11124","11129","11115","11137","11127"],"item_5_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"脂質代謝異常を呈する2型糖尿病患者に対するフェノフィブラートの効果"}]},"item_5_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"シシツ タイシャ イジョウ オ テイスル 2ガタ トウニョウビョウ カンジャ ニ タイスル フェノフィブラート ノ コウカ"}]},"item_5_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3/4","bibliographicPageEnd":"107","bibliographicPageStart":"101","bibliographicVolumeNumber":"55","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_5_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effect of fenofibrate in type 2 diabetic patients with dyslipidemia was examined. Thirteen patients with type 2 diabetes mellitus and mixed hyperlipidemia; serum total cholesterol (TC)>220 mg/dl and/or triglyceride (TG)>150 mg/dl, were included in the study. Fenofibrate was administered at daily dose from 200 to 300 mg, and following items were implemented just prior to, at 3 months after, and at 6 months after the administration: amount of serum lipid, electrophoresis of lipoprotein by the method of polyacrylamide gel electrophoresis (PAGE), quantification of cholesterol (RLP-C) and triglyceride (RLP-TG) in remnant-like particle. TC significantly decreased at 6 months after administration (p<O.05), while TG at 3 and 6 months after administration was significantly lowered (p<0.05). Concentration of RLP-C that was 16.3 mg/dl before administration of fenofibrate decreased with statistical significance to attain 6.2 mg/dl and 7.2 mg/dl in 3 and 6 months after administration, respectively (p<0.01). In the case of RLP-TG, the concentration of 92.2 mg/dl before administration was observed to be lowered with time with statistical significance to reach 28.7 mg/dl and 32.7 mg/dl in 3 and 6 months, respectively (p<0.01). The low-density lipoprotein (LDL) particle size significantly increased at 6 months after administration (p<0.05). In all cases the remnant lipoprotein was observed on PAGE before administration, the bands disappeared or decreased in 8 cases by the treatment with fenofibrate. It was suggested that fenofibrate lowered RLP-C and RLP-TG, and improved the LDL particle size in type 2 diabetics with dyslipidemia.","subitem_description_type":"Abstract"}]},"item_5_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 55(3/4), 2004, 101-107","subitem_description_type":"Other"}]},"item_5_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11122","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ムラカミ, ヒロシ"}]},{"nameIdentifiers":[{"nameIdentifier":"11123","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タマサワ, ナオキ"}]},{"nameIdentifiers":[{"nameIdentifier":"11124","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヤマト, カズミ"}]},{"nameIdentifiers":[{"nameIdentifier":"11125","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タナベ, ジュタロウ"}]},{"nameIdentifiers":[{"nameIdentifier":"11126","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カサイ, ノブヒコ"}]},{"nameIdentifiers":[{"nameIdentifier":"11127","nameIdentifierScheme":"WEKO"}],"names":[{"name":"マツイ, ジュン"}]},{"nameIdentifiers":[{"nameIdentifier":"11128","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オガワ, ヨシジ"}]},{"nameIdentifiers":[{"nameIdentifier":"11129","nameIdentifierScheme":"WEKO"}],"names":[{"name":"スダ, トシヒロ"}]}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11130","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Murakami, Hiroshi"}]},{"nameIdentifiers":[{"nameIdentifier":"11131","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tamasawa, Naoki"}]},{"nameIdentifiers":[{"nameIdentifier":"11132","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yamato, Kazumi"}]},{"nameIdentifiers":[{"nameIdentifier":"11133","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tanabe, Jutaro"}]},{"nameIdentifiers":[{"nameIdentifier":"11134","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kasai, Nobuhiko"}]},{"nameIdentifiers":[{"nameIdentifier":"11135","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Matsui, Jun"}]},{"nameIdentifiers":[{"nameIdentifier":"11136","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Guan, Jing-Zhi"}]},{"nameIdentifiers":[{"nameIdentifier":"11137","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Ogawa, Yoshiji"}]},{"nameIdentifiers":[{"nameIdentifier":"11138","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Suda, Toshihiro"}]}]},"item_5_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学医学部・弘前医学会"}]},"item_5_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_5_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_5_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_5_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_5_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Third Department of Internal Medicine, Hirosaki University School of Medicine"},{"subitem_text_value":"Third Department of Internal Medicine, Hirosaki University School of Medicine"},{"subitem_text_value":"Third Department of Internal Medicine, Hirosaki University School of Medicine"},{"subitem_text_value":"Third Department of Internal Medicine, Hirosaki University School of Medicine"},{"subitem_text_value":"Third Department of Internal Medicine, Hirosaki University School of Medicine"},{"subitem_text_value":"Third Department of Internal Medicine, Hirosaki University School of Medicine"},{"subitem_text_value":"Third Department of Internal Medicine, Hirosaki University School of Medicine"},{"subitem_text_value":"Third Department of Internal Medicine, Hirosaki University School of Medicine"},{"subitem_text_value":"Third Department of Internal Medicine, Hirosaki University School of Medicine"},{"subitem_text_value":"弘前大学医学部第三内科"},{"subitem_text_value":"弘前大学医学部第三内科"},{"subitem_text_value":"弘前大学医学部第三内科"},{"subitem_text_value":"弘前大学医学部第三内科"},{"subitem_text_value":"弘前大学医学部第三内科"},{"subitem_text_value":"弘前大学医学部第三内科"},{"subitem_text_value":"弘前大学医学部第三内科"},{"subitem_text_value":"弘前大学医学部第三内科"},{"subitem_text_value":"弘前大学医学部第三内科"}]},"item_5_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"村上, 宏"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"玉澤, 直樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大和, 一美"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田辺, 壽太郎"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"葛西, 伸彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松井, 淳"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"管, 静芝"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小川, 吉司"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"須田, 俊宏"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"KJ00004100950.pdf","filesize":[{"value":"488.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004100950.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3573/files/KJ00004100950.pdf"},"version_id":"289ae324-477f-40a9-bdee-67b4ff9b884f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"small","subitem_subject_scheme":"Other"},{"subitem_subject":"dence LDL","subitem_subject_scheme":"Other"},{"subitem_subject":"remnant lipoprotein","subitem_subject_scheme":"Other"},{"subitem_subject":"remnant-like particle","subitem_subject_scheme":"Other"},{"subitem_subject":"小型高比重LDL","subitem_subject_scheme":"Other"},{"subitem_subject":"レムナントリポ蛋白","subitem_subject_scheme":"Other"},{"subitem_subject":"レムナント粒子","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"EFFECT OF FENOFIBRATE ON LIPID LEVELS OF TYPE 2 DIABETIC PATIENTS WITH DYSLIPIDEMIA","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"EFFECT OF FENOFIBRATE ON LIPID LEVELS OF TYPE 2 DIABETIC PATIENTS WITH DYSLIPIDEMIA"}]},"item_type_id":"5","owner":"3","path":["635"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-12-06"},"publish_date":"2006-12-06","publish_status":"0","recid":"3573","relation_version_is_last":true,"title":["EFFECT OF FENOFIBRATE ON LIPID LEVELS OF TYPE 2 DIABETIC PATIENTS WITH DYSLIPIDEMIA"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:22:49.413178+00:00"}