{"created":"2023-05-15T09:02:42.642995+00:00","id":3575,"links":{},"metadata":{"_buckets":{"deposit":"e06e56b2-a3c8-4a89-a8f5-45a965b5e62e"},"_deposit":{"created_by":3,"id":"3575","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3575"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003575","sets":["557:561:636"]},"author_link":["11672","11146","11163","11158","7131","11153","11147","11145","11152","11154","11161","11156","11165","11164","11149","11144","11166","11148","11157","11160","11162","11151","11150","11155"],"item_5_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"共培養法により明らかになった乾癬における表皮細胞-線維芽細胞の相互作用の変化"}]},"item_5_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"キョウサイボウ バイヨウ ニヨリ アキラカニ ナッタ カンセン ニオケル ヒョウヒ サイボウ センイガサイボウ ノ ソウゴ サヨウ ノ ヘンカ"}]},"item_5_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-10-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"8","bibliographicPageStart":"1","bibliographicVolumeNumber":"56","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_5_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Psoriatic skin is composed of inflammatory epidermal and dermal tissues. We hypothesized that cell to cell interactions by means of cytokine response may be altered in psoriasis. In order to define this theory, in vitro experiments were carried out using the cell culture system. Psoriatic keratinocytes and fibroblasts were simultaneously co-cultured on each side of the collagen membrane in the medium of high calcium condition to identify the interactions between keratinocytes and fibroblasts. We also carried out several combined cultures of normal or psoriatic keratinocytes and fibroblasts. In the culture fluid of-combined cell-culture, the level of interleukin-6 (IL-6) was significantly higher in the combination of psoriatic keratinocytes and fibroblasts compared with that using normal keratinocytes. Psoriatic keratinocytes significantly secreted larger amounts of transforming growth factor-α (TGF-α) compared with normal keratinocytes when they were solely cultured. However, TGF-α secretion of normal keratinocytes was suppressed by co-culture with psoriatic fibroblasts, by which psoriatic keratinocytes were not influenced. These results indicate that the altered interaction between keratinocytes and fibroblasts exists in the psoriatic lesion, and it might occur in abnormal keratinocyte proliferation and differentiation.","subitem_description_type":"Abstract"}]},"item_5_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 56(1), 2004, 1-8","subitem_description_type":"Other"}]},"item_5_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"7131","nameIdentifierScheme":"WEKO"}],"names":[{"name":"キクチ, トモコ"}]},{"nameIdentifiers":[{"nameIdentifier":"11160","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ミツハシ, ヨシヒコ"}]},{"nameIdentifiers":[{"nameIdentifier":"11161","nameIdentifierScheme":"WEKO"}],"names":[{"name":"マツザキ, ヤスシ"}]},{"nameIdentifiers":[{"nameIdentifier":"11162","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カネコ, タカヒデ"}]},{"nameIdentifiers":[{"nameIdentifier":"11163","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナカノ, ハジメ"}]},{"nameIdentifiers":[{"nameIdentifier":"11164","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タケダ, ヒトシ"}]},{"nameIdentifiers":[{"nameIdentifier":"11165","nameIdentifierScheme":"WEKO"}],"names":[{"name":"モリツグ, リュウタ"}]},{"nameIdentifiers":[{"nameIdentifier":"11166","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハナダ, カツミ"}]}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11151","nameIdentifierScheme":"WEKO"}],"names":[{"name":"菊池, 朋子"}]},{"nameIdentifiers":[{"nameIdentifier":"11152","nameIdentifierScheme":"WEKO"}],"names":[{"name":"三橋, 善比古"}]},{"nameIdentifiers":[{"nameIdentifier":"11153","nameIdentifierScheme":"WEKO"}],"names":[{"name":"松崎, 康司"}]},{"nameIdentifiers":[{"nameIdentifier":"11154","nameIdentifierScheme":"WEKO"}],"names":[{"name":"金子, 高英"}]},{"nameIdentifiers":[{"nameIdentifier":"11155","nameIdentifierScheme":"WEKO"}],"names":[{"name":"中野, 創"}]},{"nameIdentifiers":[{"nameIdentifier":"11156","nameIdentifierScheme":"WEKO"}],"names":[{"name":"武田, 仁志"}]},{"nameIdentifiers":[{"nameIdentifier":"11157","nameIdentifierScheme":"WEKO"}],"names":[{"name":"森次, 龍太"}]},{"nameIdentifiers":[{"nameIdentifier":"11158","nameIdentifierScheme":"WEKO"}],"names":[{"name":"花田, 勝美"}]}]},"item_5_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学医学部・弘前医学会"}]},"item_5_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_5_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_5_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_5_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_5_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Dermatology, Hirosaki University School of Medicine"},{"subitem_text_value":"Department of Dermatology, Yamagata University School of Medicine"},{"subitem_text_value":"Department of Dermatology, Hirosaki University School of Medicine"},{"subitem_text_value":"Department of Dermatology, Hirosaki University School of Medicine"},{"subitem_text_value":"Department of Dermatology, Hirosaki University School of Medicine"},{"subitem_text_value":"Department of Dermatology, Hirosaki University School of Medicine"},{"subitem_text_value":"Department of Dermatology, Hirosaki University School of Medicine"},{"subitem_text_value":"Department of Dermatology, Hirosaki University School of Medicine"},{"subitem_text_value":"弘前大学医学部皮膚科教室"},{"subitem_text_value":"山形大学医学部皮膚科教室"},{"subitem_text_value":"弘前大学医学部皮膚科教室"},{"subitem_text_value":"弘前大学医学部皮膚科教室"},{"subitem_text_value":"弘前大学医学部皮膚科教室"},{"subitem_text_value":"弘前大学医学部皮膚科教室"},{"subitem_text_value":"弘前大学医学部皮膚科教室"},{"subitem_text_value":"弘前大学医学部皮膚科教室"}]},"item_5_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kikuchi, Tomoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mitsuhashi, Yoshihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuzaki, Yasushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kaneko, Takahide"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakano, Hajime"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Takeda, Hitoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Moritsugu, Ryuta"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hanada, Katsumi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"KJ00004119221.pdf","filesize":[{"value":"489.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004119221.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3575/files/KJ00004119221.pdf"},"version_id":"1eaaa7c6-2475-4b5f-a14c-64512a28a1f2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"psoriasis","subitem_subject_scheme":"Other"},{"subitem_subject":"keratinocyte-fibroblast interaction","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-6","subitem_subject_scheme":"Other"},{"subitem_subject":"TGF-α","subitem_subject_scheme":"Other"},{"subitem_subject":"cell-culture","subitem_subject_scheme":"Other"},{"subitem_subject":"乾癬","subitem_subject_scheme":"Other"},{"subitem_subject":"表皮細胞-線維芽細胞の相互作用","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞培養","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ALTERED KERATINOCYTE-FIBROBLAST INTERACTIONS IN PSORIASIS REVEALED BY A COMBINED CELL-CULTURE","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ALTERED KERATINOCYTE-FIBROBLAST INTERACTIONS IN PSORIASIS REVEALED BY A COMBINED CELL-CULTURE"}]},"item_type_id":"5","owner":"3","path":["636"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-12-06"},"publish_date":"2006-12-06","publish_status":"0","recid":"3575","relation_version_is_last":true,"title":["ALTERED KERATINOCYTE-FIBROBLAST INTERACTIONS IN PSORIASIS REVEALED BY A COMBINED CELL-CULTURE"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:08:30.946495+00:00"}