@article{oai:hirosaki.repo.nii.ac.jp:00003583,
 author = {Watanabe, Tomoko and Tamura, Yoshihiro and Tsushima, Kenichi and Munakata, Akihiro},
 issue = {2/3/4},
 journal = {弘前医学},
 month = {Mar},
 note = {application/pdf, To evaluate the clinical significance of p53 mutations, we analyzed the relationship of several clinicopathologic factors to the clinical outcomes in 131 colorectal cancer patients. Exons 5 to 9 of the p53 gene were studied by the direct sequencing method with capillary electrophoresis. A total of 47 mutations of p53 were found, in 45 of 131 cases (34%). Mutations were statistically associated with lymphatic invasion (p=0.03) and lymph node metastasis (p=0.02). Kaplan-Meier survival curves for the patients with p53 mutations were likely to exhibit shortened survivals, but the difference was not statistically significant (p=0.078). In our evaluation of each exon in relationship to survival, p53 mutations in exon 7 correlated significantly with poor prognosis (p=0.041). In multivariate analysis, p53 mutation emerged as an independent marker for prognostic hazard ratio= 1.650 (p=0.015). However, exon 7 mutations were not related to survival, as well other exons and specific type of mutations. Investigation of p53 mutation overall was considered to be a clinically usefull approach for determining the prognosis of patients with colorectal cancer., 弘前医学. 56(2/3/4), 2005, 69-78},
 pages = {69--78},
 title = {Prognostic Significance of P53 Mutation in Surgically Treated Colorectal Cancer : A Prospective Study Using Direct Sequencing Method},
 volume = {56},
 year = {2005}
}