{"created":"2023-05-15T09:02:43.060008+00:00","id":3583,"links":{},"metadata":{"_buckets":{"deposit":"d619359b-7ffe-44ed-ac8c-88544d1dac6e"},"_deposit":{"created_by":3,"id":"3583","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3583"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003583","sets":["557:561:637"]},"author_link":["11272","11280","11078","11074","11279","11278","11270","11275","11274","11271","11082","11276"],"item_5_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"直接シークエンス法による大腸癌手術症例におけるp53遺伝子変異の予後の検討"}]},"item_5_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"チョクセツ シークエンスホウ ニヨル ダイチョウガン シュジュツ ショウレイ ニオケル p53 イデンシ ヘンイ ノ ヨゴ ノ ケントウ"}]},"item_5_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2/3/4","bibliographicPageEnd":"78","bibliographicPageStart":"69","bibliographicVolumeNumber":"56","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_5_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To evaluate the clinical significance of p53 mutations, we analyzed the relationship of several clinicopathologic factors to the clinical outcomes in 131 colorectal cancer patients. Exons 5 to 9 of the p53 gene were studied by the direct sequencing method with capillary electrophoresis. A total of 47 mutations of p53 were found, in 45 of 131 cases (34%). Mutations were statistically associated with lymphatic invasion (p=0.03) and lymph node metastasis (p=0.02). Kaplan-Meier survival curves for the patients with p53 mutations were likely to exhibit shortened survivals, but the difference was not statistically significant (p=0.078). In our evaluation of each exon in relationship to survival, p53 mutations in exon 7 correlated significantly with poor prognosis (p=0.041). In multivariate analysis, p53 mutation emerged as an independent marker for prognostic hazard ratio= 1.650 (p=0.015). However, exon 7 mutations were not related to survival, as well other exons and specific type of mutations. Investigation of p53 mutation overall was considered to be a clinically usefull approach for determining the prognosis of patients with colorectal cancer.","subitem_description_type":"Abstract"}]},"item_5_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 56(2/3/4), 2005, 69-78","subitem_description_type":"Other"}]},"item_5_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11278","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ワタナベ, トモコ"}]},{"nameIdentifiers":[{"nameIdentifier":"11279","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タムラ, ヨシヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"11280","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ツシマ, ケンイチ"}]},{"nameIdentifiers":[{"nameIdentifier":"11078","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ムナカタ, アキヒロ"}]}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11274","nameIdentifierScheme":"WEKO"}],"names":[{"name":"渡邉, 智子"}]},{"nameIdentifiers":[{"nameIdentifier":"11275","nameIdentifierScheme":"WEKO"}],"names":[{"name":"田村, 好弘"}]},{"nameIdentifiers":[{"nameIdentifier":"11276","nameIdentifierScheme":"WEKO"}],"names":[{"name":"対馬, 健一"}]},{"nameIdentifiers":[{"nameIdentifier":"11074","nameIdentifierScheme":"WEKO"}],"names":[{"name":"棟方, 昭博"}]}]},"item_5_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学医学部・弘前医学会"}]},"item_5_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_5_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_5_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_5_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_5_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_5_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"First Department of Internal Medicine, Hirosaki University School of Medicine"},{"subitem_text_value":"弘前大学医学部内科学第一講座"}]},"item_5_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Watanabe, Tomoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tamura, Yoshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsushima, Kenichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Munakata, Akihiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"KJ00004190601.pdf","filesize":[{"value":"647.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004190601.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3583/files/KJ00004190601.pdf"},"version_id":"77d211d8-9865-40b0-8f9b-0c762a57c6d0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"colorectal cancer","subitem_subject_scheme":"Other"},{"subitem_subject":"p53 mutation","subitem_subject_scheme":"Other"},{"subitem_subject":"direct sequencing method","subitem_subject_scheme":"Other"},{"subitem_subject":"大腸癌","subitem_subject_scheme":"Other"},{"subitem_subject":"p53遺伝子変異","subitem_subject_scheme":"Other"},{"subitem_subject":"直接シークエンス法","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Prognostic Significance of P53 Mutation in Surgically Treated Colorectal Cancer : A Prospective Study Using Direct Sequencing Method","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Prognostic Significance of P53 Mutation in Surgically Treated Colorectal Cancer : A Prospective Study Using Direct Sequencing Method"}]},"item_type_id":"5","owner":"3","path":["637"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-12-07"},"publish_date":"2006-12-07","publish_status":"0","recid":"3583","relation_version_is_last":true,"title":["Prognostic Significance of P53 Mutation in Surgically Treated Colorectal Cancer : A Prospective Study Using Direct Sequencing Method"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:48:58.482297+00:00"}