{"created":"2023-05-15T09:02:43.346077+00:00","id":3588,"links":{},"metadata":{"_buckets":{"deposit":"ffe2eff3-07de-41a1-b7b1-cddd2d600064"},"_deposit":{"created_by":3,"id":"3588","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3588"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003588","sets":["557:561:638"]},"author_link":["11330","11325","11328","11329","11326","11327"],"item_5_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Demonstration of a New Genotype Encoding Uncoupling Protein 2 and Association with Obesity"}]},"item_5_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"Uncoupling Protein 2 ノ アラタナ イデンシ タガタ ノ ケンシュツ ト ヒマン トノ カンケイ ニツイテ"}]},"item_5_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"42","bibliographicPageStart":"35","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_5_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Uncoupling protein 2 (UCP2), mapped to chromosome 11q13 in humans, plays an important role in energy metabolism and body weight regulation. Some positive results have been reported for associations of obesity and diabetes in Caucasians with the polymorphism of the UCP2 gene in the 3'-untranslated region (3' UTR) of exon 8 (insertion and deletion types). We examined the genotypes of adult men in Aomori Prefecture situated in northern Japan, in order to investigate associations between the polymorphism and obesity. In the present study, in addition to the insertion type of 457bp, a new genotype composed of 502bp was detected, while the deletion type of 412bp was not. Although the sequence of inserted 45bp in the 457bp type was entirely identical to that reported previously, the fragment was inserted at the 111bp from the 3' end of the exon 8. In the 502bp type, the same fragment was further added to the 457bp type. The new genotype was observed in 4 of 18 subjects as the 457/502 heterozygote and other subjects were the 457/457 homozygote. Significant associations were found between the polymorphism of UCP2 gene and obesity in adult Japanese men. Weight, thicknesses of the subcutaneous adipose tissues at triceps and lateral abdomen, fat percentage and fatmass were significantly higher (p<0.05) in subjects with the heterozygote (457/502) than in subjects with the homozygote (457/457). These results suggest that a new genotype (502bp) is involved in obesity.","subitem_description_type":"Abstract"}]},"item_5_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 57(1), 2005, p.35-42","subitem_description_type":"Other"}]},"item_5_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11327","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ムナカタ, エイジ"}]},{"nameIdentifiers":[{"nameIdentifier":"11328","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ツチダ, シゲキ"}]}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11329","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Munakata, Eiji"}]},{"nameIdentifiers":[{"nameIdentifier":"11330","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tsuchida, Shigeki"}]}]},"item_5_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学医学部・弘前医学会"}]},"item_5_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_5_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_5_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_5_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"467","subitem_subject_scheme":"NDC"}]},"item_5_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"生物学","subitem_subject_scheme":"Other"}]},"item_5_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前大学医学部医学科生化学第二講座"},{"subitem_text_value":"弘前大学医学部医学科生化学第二講座"},{"subitem_text_value":"Second Department of Biochemistry, Hirosaki University School of Medicine"},{"subitem_text_value":"Second Department of Biochemistry, Hirosaki University School of Medicine"}]},"item_5_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"棟方, 栄治"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"土田, 成紀"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"KJ00004529550.pdf","filesize":[{"value":"584.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004529550.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3588/files/KJ00004529550.pdf"},"version_id":"f3004ccd-1694-4b68-b6e5-e8f989bc0622"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"アンカップリングプロテイン","subitem_subject_scheme":"Other"},{"subitem_subject":"β3-アドレナリンリセプター","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子多型","subitem_subject_scheme":"Other"},{"subitem_subject":"肥満","subitem_subject_scheme":"Other"},{"subitem_subject":"2uncoupling protein 2","subitem_subject_scheme":"Other"},{"subitem_subject":"β3-adrenergic receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA polymorphism","subitem_subject_scheme":"Other"},{"subitem_subject":"obesity","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Uncoupling Protein 2の新たな遺伝子多型の検出と肥満との関係について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Uncoupling Protein 2の新たな遺伝子多型の検出と肥満との関係について"}]},"item_type_id":"5","owner":"3","path":["638"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-05-01"},"publish_date":"2007-05-01","publish_status":"0","recid":"3588","relation_version_is_last":true,"title":["Uncoupling Protein 2の新たな遺伝子多型の検出と肥満との関係について"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:46:13.771588+00:00"}