{"created":"2023-05-15T09:02:43.681400+00:00","id":3593,"links":{},"metadata":{"_buckets":{"deposit":"3f1bdd1e-5b62-4356-ab5e-fb79fbd947e7"},"_deposit":{"created_by":3,"id":"3593","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3593"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003593","sets":["557:561:639"]},"author_link":["11385","11390","11403","11381","11388","11389","11404","11380","11383","14521","11023","11026","11382","11384","11387","11394","11392","11401","11879","11397","11029","11395","11398","11400","11391","11386","11393"],"item_5_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"心大血管手術後肺障害に対するシベレスタットナトリウム(エラスポール)の効果"}]},"item_5_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"シン ダイケッカン シュジュツゴ ハイ ショウガイ ニタイスル シベレスタットナトリウム エラスポール ノ コウカ"}]},"item_5_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2/3/4","bibliographicPageEnd":"86","bibliographicPageStart":"79","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_5_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Lung injury and acute respiratory distress syndrome after cardiopulmonary bypass were described as severe postoperative complication. Although the incidence of ARDS after cardiopulmonary bypass (CPB) is about 1%, the mortality of ARDS is extremely high. It has been well recognized that CPB is associated with systemic inflammation. This pulmonary dysfunction after CPB is one of those inflammatory responses, activated neutrophil and neurophil elastase play an important role in this injury. Method: ELASPOL (Sivelestat sodium hydrate; Ono Pharmaceutical Co., in Japan) is neutrophil elastase inhibitor that was introduced in 2002 for acute lung injury with SIRS. We hypothesized that this drug would reduce lung dysfunction after CPB especially in the patient who had total arch replacement or cardiac surgery with severe preoperative condition. We compared control group and group treated with ELASPOL[○!R] group retrospectively. The control group were cases of total arch replacement with severe lung dysfunction before 2002, therapeutic group were cases of total arch replacement with ELASPOL that included a case without operation. Arterial PO_2/FiO_2 as indication of lung injury (The P/F ratio is an index of acute lung injury and ARDS, it is defined as acute lung injury when the P/F ratio is under 300, and the P/F ratio of ARDS is under 200.), platelet count, WBC count, CRP, duration of intubation and ICU stay were evaluated. Results: As compared with the control group that had almost same operative procedure with ELASPOL, P/F ratio (arterial PO_2/FiO_2) was increased over 200 at four postoperative days and well maintained after all in therapeutic group. On the other hand it dropped to below 150, and it did not recovered to 200 until 10 days after the operation in the control group (p<0.05). Platelet count in ELASPOL group was relatively higher than control, but there is no significance of differences between groups. The other factors such as WBC count, CRP level, duration of intubation and ICU stay were almost equal. Conclusions: We conclude that ELASPOL is expected to reduce lung injury after CPB in the case of total arch replacement or cardiac surgery with severe preoperative condition.","subitem_description_type":"Abstract"}]},"item_5_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 57(2/3/4), 2006, p.79-86","subitem_description_type":"Other"}]},"item_5_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11388","nameIdentifierScheme":"WEKO"}],"names":[{"name":"スズキ, ヤスユキ"}]},{"nameIdentifiers":[{"nameIdentifier":"11389","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ワカヤマ, フミノリ"}]},{"nameIdentifiers":[{"nameIdentifier":"11390","nameIdentifierScheme":"WEKO"}],"names":[{"name":"コンドウ, ノリヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"11391","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タモ, ワカコ"}]},{"nameIdentifiers":[{"nameIdentifier":"11392","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タニグチ, サトシ"}]},{"nameIdentifiers":[{"nameIdentifier":"11393","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ダイトク, カズユキ"}]},{"nameIdentifiers":[{"nameIdentifier":"11394","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ミナカワ, マサヒト"}]},{"nameIdentifiers":[{"nameIdentifier":"11395","nameIdentifierScheme":"WEKO"}],"names":[{"name":"フクイ, コウゾウ"}]},{"nameIdentifiers":[{"nameIdentifier":"11026","nameIdentifierScheme":"WEKO"}],"names":[{"name":"フクダ, イクオ"}]}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11397","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Suzuki, Yasuyuki"}]},{"nameIdentifiers":[{"nameIdentifier":"11398","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Wakayama, Fuminori"}]},{"nameIdentifiers":[{"nameIdentifier":"14521","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kondo, Norihiro"}]},{"nameIdentifiers":[{"nameIdentifier":"11400","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tamo, Wakako"}]},{"nameIdentifiers":[{"nameIdentifier":"11401","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Taniguchi, Satoshi"}]},{"nameIdentifiers":[{"nameIdentifier":"11879","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"254","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/254_ja.html"}],"names":[{"name":"Daitoku, Kazuyuki"}]},{"nameIdentifiers":[{"nameIdentifier":"11403","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"251","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/251_ja.html"}],"names":[{"name":"Minakawa, Masahito"}]},{"nameIdentifiers":[{"nameIdentifier":"11404","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Fukui, Kozo"}]},{"nameIdentifiers":[{"nameIdentifier":"11029","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Fukuda, Ikuo"}]}]},"item_5_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学医学部・弘前医学会"}]},"item_5_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_5_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_5_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_5_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"494.28","subitem_subject_scheme":"NDC"}]},"item_5_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"外科系臨床医学","subitem_subject_scheme":"Other"}]},"item_5_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"First Department Surgery, Hirosaki University School of Medicine"},{"subitem_text_value":"First Department Surgery, Hirosaki University School of Medicine"},{"subitem_text_value":"First Department Surgery, Hirosaki University School of Medicine"},{"subitem_text_value":"First Department Surgery, Hirosaki University School of Medicine"},{"subitem_text_value":"First Department Surgery, Hirosaki University School of Medicine"},{"subitem_text_value":"First Department Surgery, Hirosaki University School of Medicine"},{"subitem_text_value":"First Department Surgery, Hirosaki University School of Medicine"},{"subitem_text_value":"First Department Surgery, Hirosaki University School of Medicine"},{"subitem_text_value":"First Department Surgery, Hirosaki University School of Medicine"},{"subitem_text_value":"弘前大学医学部第一外科"},{"subitem_text_value":"弘前大学医学部第一外科"},{"subitem_text_value":"弘前大学医学部第一外科"},{"subitem_text_value":"弘前大学医学部第一外科"},{"subitem_text_value":"弘前大学医学部第一外科"},{"subitem_text_value":"弘前大学医学部第一外科"},{"subitem_text_value":"弘前大学医学部第一外科"},{"subitem_text_value":"弘前大学医学部第一外科"},{"subitem_text_value":"弘前大学医学部第一外科"}]},"item_5_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鈴木, 保之"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"若山, 文規"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"近藤, 慎浩"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田茂, 和歌子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"谷口, 哲"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大徳, 和之"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"皆川, 正仁"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"福井, 康三"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"福田, 幾夫"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"KJ00004529556.pdf","filesize":[{"value":"589.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004529556.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3593/files/KJ00004529556.pdf"},"version_id":"15adca2f-92a7-4f55-8747-f2aa392dc111"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"心・大血管手術","subitem_subject_scheme":"Other"},{"subitem_subject":"人工心肺","subitem_subject_scheme":"Other"},{"subitem_subject":"肺障害","subitem_subject_scheme":"Other"},{"subitem_subject":"好中球エラスターゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"シベレスタットナトリウム(エラスポール)","subitem_subject_scheme":"Other"},{"subitem_subject":"cardiopulmonary bypass","subitem_subject_scheme":"Other"},{"subitem_subject":"lung injury","subitem_subject_scheme":"Other"},{"subitem_subject":"neutrophil elastase","subitem_subject_scheme":"Other"},{"subitem_subject":"ELASPOL (Sivelestat sodium hydrate)","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of Sivelestat Sodium Hydrate (Elaspol) for Lung Injury and Acute Respiratory Distress Syndrome after Cardiovascular Surgery","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of Sivelestat Sodium Hydrate (Elaspol) for Lung Injury and Acute Respiratory Distress Syndrome after Cardiovascular Surgery"}]},"item_type_id":"5","owner":"3","path":["639"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-05-02"},"publish_date":"2007-05-02","publish_status":"0","recid":"3593","relation_version_is_last":true,"title":["Effect of Sivelestat Sodium Hydrate (Elaspol) for Lung Injury and Acute Respiratory Distress Syndrome after Cardiovascular Surgery"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:50:06.910193+00:00"}