{"created":"2023-05-15T09:02:44.006964+00:00","id":3598,"links":{},"metadata":{"_buckets":{"deposit":"21f37d51-0888-4b50-aa57-58a1d9575889"},"_deposit":{"created_by":3,"id":"3598","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3598"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003598","sets":["557:561:640"]},"author_link":["11480","11474","11478","11475","11470","11481","11472","11477","11476","11473","11482","11479","11471"],"item_5_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"高血圧,糖尿病,血小板機能におけるバゾプレシンVla受容体の役割"}]},"item_5_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"コウケツアツ トウニョウビョウ ケッショウバン キノウ ニオケル バゾプレシンV1a ジュヨウタイ ノ ヤクワリ"}]},"item_5_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1/2/3/4","bibliographicPageEnd":"52","bibliographicPageStart":"35","bibliographicVolumeNumber":"58","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_5_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Arginine vasopressin (AVP), a peptide hormone released from the posterior pituitary, has been suggested to play important roles in cardiovascular regulation, glycogenolysis and platelet aggregation through its V1a receptor (V1aR). In this study, we investigated the association of 4 novel single nucleotide polymorphisms (SNPs) in V1aR gene (-6951G/A, -4112A/T, -3860T/C and -242C/T) with hypertension, diabetes mellitus (DM) and glycemic status, and platelet responsiveness to AVP. Genotypes were determined in 365 hypertensives and 255 healthy subjects, 186 patients with type 2 DM (T2DM) and 188 non-diabetic control subjects (CS), and 33 young healthy subjects in the Aomori prefecture. A significant association was found between the SNP -6951G/A and hypertension in nonobese individuals. Multiple logistic analysis demonstrated SNP -6951G/A as an independent risk factor for nonobese hypertension. One haplotype H3 (a-a-c-c) was characteristic to hypertension in nonobese. A significant association was found between the SNP -6951G/A and type 2 DM. Logistic regression also confirmed the significant association of the SNP -6951G/A with type 2 DM. There were a couple of characteristic distributions of heterozygous haplotype combinations in T2DM. In young healthy subjects, GA+AA carriers of SNP -6951 showed significantly higher HbAlc levels than in GG. Platelet aggregation responses to AVP were identical between wild types and variants of any SNPs. These results suggest that -6951G/A SNP and haplotypes created by 4 SNPs of V1aR gene might confer susceptibility to essential hypertension in nonobese individuals and type 2 DM. However, these SNPs might not be useful as genetic marker for platelet aggregation heterogeneity.","subitem_description_type":"Abstract"}]},"item_5_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 58(1/2/3/4), 2007, p.35-52","subitem_description_type":"Other"}]},"item_5_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11470","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hasan, Kazi N."}]},{"nameIdentifiers":[{"nameIdentifier":"11479","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ショウジ, マサル"}]},{"nameIdentifiers":[{"nameIdentifier":"11480","nameIdentifierScheme":"WEKO"}],"names":[{"name":"スギモト, カズヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"11481","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ツタヤ, ショウジ"}]},{"nameIdentifiers":[{"nameIdentifier":"11482","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヤスジマ, ミノル"}]}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11470","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hasan, Kazi N."}]},{"nameIdentifiers":[{"nameIdentifier":"11475","nameIdentifierScheme":"WEKO"}],"names":[{"name":"庄司, 優"}]},{"nameIdentifiers":[{"nameIdentifier":"11476","nameIdentifierScheme":"WEKO"}],"names":[{"name":"杉本, 一博"}]},{"nameIdentifiers":[{"nameIdentifier":"11477","nameIdentifierScheme":"WEKO"}],"names":[{"name":"蔦谷, 昭司"}]},{"nameIdentifiers":[{"nameIdentifier":"11478","nameIdentifierScheme":"WEKO"}],"names":[{"name":"保嶋, 実"}]}]},"item_5_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学医学部・弘前医学会"}]},"item_5_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_5_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_5_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_5_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.3","subitem_subject_scheme":"NDC"}]},"item_5_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_5_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Laboratory Medicine, Hirosaki University School of Medicine"},{"subitem_text_value":"Department of Laboratory Medicine, Hirosaki University School of Medicine"},{"subitem_text_value":"Department of Clinical Laboratory, Hirosaki University Hospital"},{"subitem_text_value":"Department of Clinical Laboratory, Hirosaki University Hospital"},{"subitem_text_value":"Department of Laboratory Medicine, Hirosaki University School of Medicine"},{"subitem_text_value":"弘前大学医学部臨床検査医学"},{"subitem_text_value":"弘前大学医学部臨床検査医学"},{"subitem_text_value":"弘前大学医学部附属病院検査部"},{"subitem_text_value":"弘前大学医学部附属病院検査部"},{"subitem_text_value":"弘前大学医学部臨床検査医学"}]},"item_5_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hasan, Kazi N."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shoji, Masaru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugimoto, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsutaya, Shoji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yasujima, Minoru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"KJ00004724932.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004724932.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3598/files/KJ00004724932.pdf"},"version_id":"b339850d-4ea2-4216-a992-b6c82251aeb6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"vasopressinV1a receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"SNPs","subitem_subject_scheme":"Other"},{"subitem_subject":"essential hypertension","subitem_subject_scheme":"Other"},{"subitem_subject":"nonobese Japanese","subitem_subject_scheme":"Other"},{"subitem_subject":"type 2 diabetes mellitus","subitem_subject_scheme":"Other"},{"subitem_subject":"platelet aggregation heterogeneity","subitem_subject_scheme":"Other"},{"subitem_subject":"バゾプレシンVla受容体","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子多型","subitem_subject_scheme":"Other"},{"subitem_subject":"高血圧症","subitem_subject_scheme":"Other"},{"subitem_subject":"非肥満日本人","subitem_subject_scheme":"Other"},{"subitem_subject":"糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"血小板凝集反応性","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Role of Vasopressin V1a Receptor in Hypertension, Diabetes Mellitus and Platelet Function : Genetic Polymorphism Study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Role of Vasopressin V1a Receptor in Hypertension, Diabetes Mellitus and Platelet Function : Genetic Polymorphism Study"}]},"item_type_id":"5","owner":"3","path":["640"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-12-26"},"publish_date":"2007-12-26","publish_status":"0","recid":"3598","relation_version_is_last":true,"title":["Role of Vasopressin V1a Receptor in Hypertension, Diabetes Mellitus and Platelet Function : Genetic Polymorphism Study"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:58:17.333579+00:00"}