{"created":"2023-05-15T09:02:44.136435+00:00","id":3600,"links":{},"metadata":{"_buckets":{"deposit":"883eba46-b300-434e-9a2a-291eb0929d0a"},"_deposit":{"created_by":3,"id":"3600","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3600"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003600","sets":["557:561:641"]},"author_link":["11516","11163","11514","11158","11147","11515","11519","11513","11521","11518","11523","11166","11525","11526","11531","11517","11528","11150","11155","11524","11530"],"item_5_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"230-kD類天疱瘡抗原発現に対するTGF-βの抑制効果"}]},"item_5_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"230-kDルイ テンホウソウ コウゲン ハッソウ ニ タイスル TGF-β ノ ヨクセイ コウカ"}]},"item_5_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"14","bibliographicPageStart":"7","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_5_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"230-kD bullous pemphigoid antigen (BPAG1) is known as an autoantigen in bullous pemphigoid and is\nexpressed exclusively in proliferating basal keratinocytes. TGF-β is a growth factor that has pleiotropic effects on\na wide range of target cells and induces differentiation of basal keratinocytes. Therefore. TGF-β is postulated to\ninhibit BPAG1 expression. However. previous report conversely demonstrated an increase of BPAG1 expression\nby TGF-β. In this study. to understand regulatory role of TGF-β on BPAG1 functions. we examined the effect\nof TGF-β on BPAG1 gene expression using cultured keratinocytes. This study showed that BPAG1 mRNA\nexpression was inhibited by TGF-β1 in concentration higher than 1.0 ng/ml. Furthermore. incubation of the\ncells with TGF-β1 in the presence of cycloheximide demonstrated that newly synthesized protein was required\nfor BPAG1 regulation. To understand the detailed mechanisms of BPAGI modulation by TGF-β, we preformed\ntransient transfection assay with a BPAGI promoter-CAT construct to know the detailed mechanisms of BPAG1\nmodulation by TGF-β. The results revealed that calcium and IFN-γ inhibited BPAG1 expression at transcriptional\nlevel, but TGF-β1 is not responsible for that transcriptional inhibition, suggesting that TGF-β may have differential\nmolecular mechanism for down-regulation of BPAG1 gene expression from the events induced by IFN-γ.","subitem_description_type":"Abstract"}]},"item_5_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59, 2007, p.7-14","subitem_description_type":"Other"}]},"item_5_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11518","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハラダ, ケン"}]},{"nameIdentifiers":[{"nameIdentifier":"11519","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タマイ, カツト"}]},{"nameIdentifiers":[{"nameIdentifier":"11163","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナカノ, ハジメ"}]},{"nameIdentifiers":[{"nameIdentifier":"11521","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ササキ, チアキ"}]},{"nameIdentifiers":[{"nameIdentifier":"11166","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハナダ, カツミ"}]},{"nameIdentifiers":[{"nameIdentifier":"11523","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハシモト, イサオ"}]},{"nameIdentifiers":[{"nameIdentifier":"11524","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サワムラ, ダイスケ"}]}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11525","nameIdentifierScheme":"WEKO"}],"names":[{"name":"原田, 研"}]},{"nameIdentifiers":[{"nameIdentifier":"11526","nameIdentifierScheme":"WEKO"}],"names":[{"name":"玉井, 克人"}]},{"nameIdentifiers":[{"nameIdentifier":"11155","nameIdentifierScheme":"WEKO"}],"names":[{"name":"中野, 創"}]},{"nameIdentifiers":[{"nameIdentifier":"11528","nameIdentifierScheme":"WEKO"}],"names":[{"name":"佐々木, 千秋"}]},{"nameIdentifiers":[{"nameIdentifier":"11158","nameIdentifierScheme":"WEKO"}],"names":[{"name":"花田, 勝美"}]},{"nameIdentifiers":[{"nameIdentifier":"11530","nameIdentifierScheme":"WEKO"}],"names":[{"name":"橋本, 功"}]},{"nameIdentifiers":[{"nameIdentifier":"11531","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"268","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/268_ja.html"}],"names":[{"name":"澤村, 大輔"}]}]},"item_5_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_5_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_5_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_5_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1713","subitem_source_identifier_type":"ISSN"}]},"item_5_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"494.8","subitem_subject_scheme":"NDC"}]},"item_5_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"外科系臨床医学","subitem_subject_scheme":"Other"}]},"item_5_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Dermatology Section. Aomori Prefectural Central Hospital"},{"subitem_text_value":"Dermatology Section. Aomori Prefectural Central Hospital"},{"subitem_text_value":"Dermatology Section. Aomori Prefectural Central Hospital"},{"subitem_text_value":"Dermatology Section. Aomori Prefectural Central Hospital"},{"subitem_text_value":"Dermatology Section. Aomori Prefectural Central Hospital"},{"subitem_text_value":"Dermatology Section. Aomori Prefectural Central Hospital"},{"subitem_text_value":"Dermatology Section. Aomori Prefectural Central Hospital"},{"subitem_text_value":"青森県立中央病院皮膚科"},{"subitem_text_value":"青森県立中央病院皮膚科"},{"subitem_text_value":"青森県立中央病院皮膚科"},{"subitem_text_value":"青森県立中央病院皮膚科"},{"subitem_text_value":"青森県立中央病院皮膚科"},{"subitem_text_value":"青森県立中央病院皮膚科"},{"subitem_text_value":"青森県立中央病院皮膚科"}]},"item_5_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Harada, Ken"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tamai, Katsuto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakano, Hajime"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Sasaki, Chiaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hanada, Katsumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hashimoto, Isao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sawamura, Daisuke"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"AN00211444_59_7.pdf","filesize":[{"value":"432.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00211444_59_7.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3600/files/AN00211444_59_7.pdf"},"version_id":"25ea7bb4-8e0b-47be-8a3b-7f7c6206d9ab"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Keratinocyte","subitem_subject_scheme":"Other"},{"subitem_subject":"BPAG1","subitem_subject_scheme":"Other"},{"subitem_subject":"TGF-β","subitem_subject_scheme":"Other"},{"subitem_subject":"IFN-γ","subitem_subject_scheme":"Other"},{"subitem_subject":"表皮細胞","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Inhibitory Effect of TGF-β on Expression of 230KD Bullous Pemphigoid Antigen","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibitory Effect of TGF-β on Expression of 230KD Bullous Pemphigoid Antigen"}]},"item_type_id":"5","owner":"3","path":["641"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-07-27"},"publish_date":"2008-07-27","publish_status":"0","recid":"3600","relation_version_is_last":true,"title":["Inhibitory Effect of TGF-β on Expression of 230KD Bullous Pemphigoid Antigen"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:59:49.507160+00:00"}