{"created":"2023-05-15T09:02:44.337967+00:00","id":3604,"links":{},"metadata":{"_buckets":{"deposit":"df10df8d-4dc1-47e3-bedc-976d3802d1d8"},"_deposit":{"created_by":3,"id":"3604","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3604"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003604","sets":["557:561:641"]},"author_link":["11589","11598","11590","11600","11594","11591","11602","11588","11595","11585","11609","11596","11586","11579","11583","11606","11597","11607","11604","11593","11580","11592","11584","13951","11601","11587","11582","11610","11603","11608","11581","11599"],"item_5_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Investigation of Active Bacillus Calmette-Guerin (BCG) Component on Bladder Cancer Cell Line"}]},"item_5_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ボウコウガン サイボウ ニ コウシュヨウ コウカ オ ハッキスル Bacillus Calmette-Guérin(BCG) キンタイ セイブン ノ タンサク"}]},"item_5_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"48","bibliographicPageStart":"41","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_5_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"表在性勝朕癌に対するBacillusCalmette-Guérin(BCG)膜状注入療法の有効性は広く認められているが,生菌で\nあるため副作用の頻度が高く,しばしば重篤な有害事象も認められる.本研究ではBCGに含まれる効果的な成分を兄い\nだすことを目的にBCGの菌体を分画し.その抗腫蕩効果を検討した.BCG (Tokyo172株)を超音波処理またはオート\nクレーブ処理後,遠心分離して上清と沈連に分画し,ヒト勝脱癌細胞株5637と混合培養した.BCG生菌と超音波処理\nまたはオートクレーブ処理上清画分は5637細胞の増殖を抑制し,ギムザ染色及びフローサイトメトリー解析によりアポ\nトーシスが検出された.これらの結果は,上清中の成分がアポトーシスを介して5637細胞に細胞増殖抑制効果をもたら\nすことを示唆し,これらの画分を精製することにより.より効果的で副作用の少ない新しい抗腫蕩薬の創薬が期待される.","subitem_description_type":"Abstract"}]},"item_5_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59, 2007, p.41-48","subitem_description_type":"Other"}]},"item_5_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11590","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヨシカワ, カズアキ"}]},{"nameIdentifiers":[{"nameIdentifier":"11591","nameIdentifierScheme":"WEKO"}],"names":[{"name":"モリ, カズユキ"}]},{"nameIdentifiers":[{"nameIdentifier":"11592","nameIdentifierScheme":"WEKO"}],"names":[{"name":"クドウ, セイジ"}]},{"nameIdentifiers":[{"nameIdentifier":"11593","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヨネヤマ, 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Kazuyuki"}]},{"nameIdentifiers":[{"nameIdentifier":"11602","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kudoh, Seiji"}]},{"nameIdentifiers":[{"nameIdentifier":"11603","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Liu, XingXing"}]},{"nameIdentifiers":[{"nameIdentifier":"11604","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Yoneyama, Takahiro"}]},{"nameIdentifiers":[{"nameIdentifier":"13951","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"467","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/467_ja.html"}],"names":[{"name":"Hashimoto, Yasuhiro"}]},{"nameIdentifiers":[{"nameIdentifier":"11606","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Koie, Takuya"}]},{"nameIdentifiers":[{"nameIdentifier":"11607","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kamimura, Noritaka"}]},{"nameIdentifiers":[{"nameIdentifier":"11608","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Takahashi, 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of Urology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Urology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Urology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Urology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Urology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Urology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Urology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Urology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Urology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Urology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Urology, Hirosaki University Graduate 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