{"created":"2023-05-15T09:02:44.381629+00:00","id":3605,"links":{},"metadata":{"_buckets":{"deposit":"07dfd97e-0301-4156-9d19-f16861de56a2"},"_deposit":{"created_by":3,"id":"3605","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3605"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003605","sets":["557:561:642"]},"author_link":["11135","11618","11114","11138","11118","11120","11113","11123","11116","15750","11130","11128","11121","11627","11131","11133","11613","11122","11125","11129","11137","11127","11619","11626"],"item_5_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"アンギオテンシノーゲン遺伝子235T alleleを有する2型糖尿病腎症患者におけるACE阻害剤とARB併用によるアルブミン尿改善効果"}]},"item_5_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"アンギオテンシノーゲン イデンシ 235T allete オ ユウスル 2ガタ トウニョウビョウ ジンショウ カンジャ ニ オケル ACE ソガイザイ ト ARB ヘイヨウ ニヨル アルブミンニョウ カイゼン コウカ"}]},"item_5_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2/3/4","bibliographicPageEnd":"64","bibliographicPageStart":"59","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_5_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We evaluated the combination therapy of angiotensin-converting-enzyme inhibitor (ACE-I) and angiotensin II type 1 receptor blocker (ARB) offered an additional effect in reduction of albuminuria in type 2 diabetic patients with angiotensinogen (AGT) M235T polymorphism. The study subjects were type 2 diabetic patients with nephropathy who were attending Hirosaki University Hospital. Fifteen patients with 235T allele (TT genotype 9, MT genotype 6) were evaluated who had diabetic nephropathy in stage 2 or 3 and already treated with ACE-I. Each patient administrated ARB (20-40 mg of termisartan) in addition to ACE-I for 16 weeks as the combination therapy. The addition of termisartan induced a significant reduction in systolic blood pressure (BP) of 14.0 mmHg and diastolic BP of 5.4mmHg. The urinary albumin-creatinine ratio (ACR) was also reduced to 48.9%. There was no significant correlation between the reduction rate of ACR and the antihypertensive response of systolic blood pressure (BP) (rs = 0.1277) and of diastolic BP (rs=0.1420) by the addition of termisartan. These results indicated that the combination of ACE-I and ARB had an additional effect on urinary albumin excretion in type 2 diabetic patients with AGT 235T allele.","subitem_description_type":"Abstract"}]},"item_5_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59, 2008, p.59-64","subitem_description_type":"Other"}]},"item_5_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11127","nameIdentifierScheme":"WEKO"}],"names":[{"name":"マツイ, ジュン"}]},{"nameIdentifiers":[{"nameIdentifier":"11128","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オガワ, ヨシジ"}]},{"nameIdentifiers":[{"nameIdentifier":"11123","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タマサワ, ナオキ"}]},{"nameIdentifiers":[{"nameIdentifier":"11618","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヤマシタ, マキ"}]},{"nameIdentifiers":[{"nameIdentifier":"11619","nameIdentifierScheme":"WEKO"}],"names":[{"name":"マツキ, コウタ"}]},{"nameIdentifiers":[{"nameIdentifier":"11125","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タナベ, ジュタロウ"}]},{"nameIdentifiers":[{"nameIdentifier":"11122","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ムラカミ, ヒロシ"}]},{"nameIdentifiers":[{"nameIdentifier":"11129","nameIdentifierScheme":"WEKO"}],"names":[{"name":"スダ, トシヒロ"}]}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11118","nameIdentifierScheme":"WEKO"}],"names":[{"name":"松井, 淳"}]},{"nameIdentifiers":[{"nameIdentifier":"11120","nameIdentifierScheme":"WEKO"}],"names":[{"name":"小川, 吉司"}]},{"nameIdentifiers":[{"nameIdentifier":"11114","nameIdentifierScheme":"WEKO"}],"names":[{"name":"玉澤, 直樹"}]},{"nameIdentifiers":[{"nameIdentifier":"11626","nameIdentifierScheme":"WEKO"}],"names":[{"name":"山下, 真紀"}]},{"nameIdentifiers":[{"nameIdentifier":"11627","nameIdentifierScheme":"WEKO"}],"names":[{"name":"松木, 恒太"}]},{"nameIdentifiers":[{"nameIdentifier":"11116","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100000316","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/100000316_ja.html"}],"names":[{"name":"田辺, 壽太郎"}]},{"nameIdentifiers":[{"nameIdentifier":"11113","nameIdentifierScheme":"WEKO"}],"names":[{"name":"村上, 宏"}]},{"nameIdentifiers":[{"nameIdentifier":"11121","nameIdentifierScheme":"WEKO"}],"names":[{"name":"須田, 俊宏"}]}]},"item_5_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_5_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_5_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_5_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_5_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.1","subitem_subject_scheme":"NDC"}]},"item_5_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_5_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Endocrinology, Metabolism and Infectious Diseases, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Endocrinology, Metabolism and Infectious Diseases, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Endocrinology, Metabolism and Infectious Diseases, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Endocrinology, Metabolism and Infectious Diseases, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Endocrinology, Metabolism and Infectious Diseases, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Endocrinology, Metabolism and Infectious Diseases, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Endocrinology, Metabolism and Infectious Diseases, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Endocrinology, Metabolism and Infectious Diseases, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"弘前大学大学院医学研究科内分泌代謝内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科内分泌代謝内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科内分泌代謝内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科内分泌代謝内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科内分泌代謝内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科内分泌代謝内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科内分泌代謝内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科内分泌代謝内科学講座"}]},"item_5_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsui, Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogawa, Yoshiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tamasawa, Naoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamashita, Maki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuki, Kota"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanabe, Jutaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murakami, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suda, Toshihiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"AN00211444_59_59.pdf","filesize":[{"value":"395.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00211444_59_59.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3605/files/AN00211444_59_59.pdf"},"version_id":"fa46d705-1fc6-4875-94f1-c10c81685aac"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"renin-angiotensin system","subitem_subject_scheme":"Other"},{"subitem_subject":"angiotensinogen 235T allele","subitem_subject_scheme":"Other"},{"subitem_subject":"type 2 diabetic nephropathy","subitem_subject_scheme":"Other"},{"subitem_subject":"angiotensin-converting-enzyme inhibitor","subitem_subject_scheme":"Other"},{"subitem_subject":"angiotensin II type 1 receptor blocker","subitem_subject_scheme":"Other"},{"subitem_subject":"レニン-アンギオテンシン-アルドステロン系","subitem_subject_scheme":"Other"},{"subitem_subject":"アンギオテンシノーゲン遺伝子235T allele","subitem_subject_scheme":"Other"},{"subitem_subject":"アンギオテンシン変換酵素阻害薬","subitem_subject_scheme":"Other"},{"subitem_subject":"アンギオテンシンII受容体拮抗薬","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Additional Effect in Reduction of Albuminuria Due to the Combination Therapy of Angiotensin-Converting-Enzyme Inhibitor and Angiotensin II Type 1 Receptor Blocker in Type 2 Diabetic Patients with the Angiotensinogen 235T Allele","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Additional Effect in Reduction of Albuminuria Due to the Combination Therapy of Angiotensin-Converting-Enzyme Inhibitor and Angiotensin II Type 1 Receptor Blocker in Type 2 Diabetic Patients with the Angiotensinogen 235T Allele"}]},"item_type_id":"5","owner":"3","path":["642"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-07-27"},"publish_date":"2008-07-27","publish_status":"0","recid":"3605","relation_version_is_last":true,"title":["Additional Effect in Reduction of Albuminuria Due to the Combination Therapy of Angiotensin-Converting-Enzyme Inhibitor and Angiotensin II Type 1 Receptor Blocker in Type 2 Diabetic Patients with the Angiotensinogen 235T Allele"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:45:56.252004+00:00"}