@article{oai:hirosaki.repo.nii.ac.jp:00003607,
 author = {Narita, Koji and Hu, Dong-Liang and Tsuji, Takao and Nakane, Akio},
 issue = {2/3/4},
 journal = {弘前医学},
 month = {Mar},
 note = {application/pdf, Toxic shock syndrome toxin 1 (TSST-l) produced by Staphylococcus aureus is one of superantigenic exotoxins and is best known for its involvement in toxic shock syndrome. To investigate whether an intranasal vaccination with a nontoxic mutant TSST-1 (mTSST-l) can protect against systemic infection and nasal colonization of S. aureus, mice were immunized with mTSST-1 plus a nontoxic mutant heat labile toxin (mLT) of Escherichia coli. After an intravenous challenge with S. aureus. bacterial growth in the organs of immunized mice reduced and the survival rate was significantly higher, compared with the naive mice. To evaluate the effect of vaccination with mTSST-l against nasal S. aureus colonization. mice were challenged with S. aureus intranasally. The bacterial counts in the nasal cavity of immunized mice were significantly reduced. Vaccination with mTSST-l plus mLT efficiently induced anti-TSST-l antibodies in the sera and mucosal exudates. and increased anti-TSST-l IgA-secreting cells in nasal-associated lymphoid tissues. These results indicate that an intranasal vaccination with mTSST-l plus mLT could induce systemic and mucosal immune responses and provide protection against not only systemic infection but also nasal colonization of S. aureus., 弘前医学. 59, 2008, p.71-82},
 pages = {71--82},
 title = {Protective Effect of Intranasal Vaccination with Nontoxic Mutant Toxic Shock Syndrome Toxin 1 against Staphylococcus Aureus Infections},
 volume = {59},
 year = {2008}
}