{"created":"2023-05-15T09:02:44.469588+00:00","id":3607,"links":{},"metadata":{"_buckets":{"deposit":"579627fe-da66-4c3a-a545-cc6b69fb0c7e"},"_deposit":{"created_by":3,"id":"3607","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3607"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003607","sets":["557:561:642"]},"author_link":["12618","11493","11654","11483","11486","11512","11492","11494","11652","11659","11502","11501"],"item_5_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"無毒変異TSST-1経鼻粘膜ワクチンによる黄色ブドウ球菌感染防御効果"}]},"item_5_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ムドク ヘンイ TSST-1 ケイビ ネンマク ワクチン ニヨル オウショク ブドウキュウキン カンセン ボウギョ コウカ"}]},"item_5_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2/3/4","bibliographicPageEnd":"82","bibliographicPageStart":"71","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_5_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Toxic shock syndrome toxin 1 (TSST-l) produced by Staphylococcus aureus is one of superantigenic exotoxins and is best known for its involvement in toxic shock syndrome. To investigate whether an intranasal vaccination with a nontoxic mutant TSST-1 (mTSST-l) can protect against systemic infection and nasal colonization of S. aureus, mice were immunized with mTSST-1 plus a nontoxic mutant heat labile toxin (mLT) of Escherichia coli. After an intravenous challenge with S. aureus. bacterial growth in the organs of immunized mice reduced and the survival rate was significantly higher, compared with the naive mice. To evaluate the effect of vaccination with mTSST-l against nasal S. aureus colonization. mice were challenged with S. aureus intranasally. The bacterial counts in the nasal cavity of immunized mice were significantly reduced. Vaccination with mTSST-l plus mLT efficiently induced anti-TSST-l antibodies in the sera and mucosal exudates. and increased anti-TSST-l IgA-secreting cells in nasal-associated lymphoid tissues. These results indicate that an intranasal vaccination with mTSST-l plus mLT could induce systemic and mucosal immune responses and provide protection against not only systemic infection but also nasal colonization of S. aureus.","subitem_description_type":"Abstract"}]},"item_5_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59, 2008, p.71-82","subitem_description_type":"Other"}]},"item_5_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11494","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナリタ, コウジ"}]},{"nameIdentifiers":[{"nameIdentifier":"11654","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ツジ, タカオ"}]},{"nameIdentifiers":[{"nameIdentifier":"11493","nameIdentifierScheme":"WEKO"}],"names":[{"name":"フウ, ドンリャン"}]},{"nameIdentifiers":[{"nameIdentifier":"11501","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナカネ, アキオ"}]}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11486","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"215","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/215_ja.html"}],"names":[{"name":"成田, 浩司"}]},{"nameIdentifiers":[{"nameIdentifier":"11483","nameIdentifierScheme":"WEKO"}],"names":[{"name":"胡, 東良"}]},{"nameIdentifiers":[{"nameIdentifier":"11659","nameIdentifierScheme":"WEKO"}],"names":[{"name":"辻, 孝雄"}]},{"nameIdentifiers":[{"nameIdentifier":"11492","nameIdentifierScheme":"WEKO"}],"names":[{"name":"中根, 明夫"}]}]},"item_5_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_5_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_5_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_5_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_5_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.7","subitem_subject_scheme":"NDC"}]},"item_5_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_5_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前大学大学院医学研究科感染生体防御学講座"},{"subitem_text_value":"弘前大学大学院医学研究科感染生体防御学講座"},{"subitem_text_value":"藤田保健衛生大学医学部微生物学講座"},{"subitem_text_value":"弘前大学大学院医学研究科感染生体防御学講座"},{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Microbiology, Fujita Health University, School of Medicine"},{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"}]},"item_5_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Narita, Koji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hu, Dong-Liang"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuji, Takao"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakane, Akio"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"AN00211444_59_71.pdf","filesize":[{"value":"788.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00211444_59_71.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3607/files/AN00211444_59_71.pdf"},"version_id":"aaabde21-fc11-4b77-aab2-9acd077477f3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Mutant toxic shock syndrome toxin-1","subitem_subject_scheme":"Other"},{"subitem_subject":"Intranasal vaccination","subitem_subject_scheme":"Other"},{"subitem_subject":"Nasal S. aureus colonization","subitem_subject_scheme":"Other"},{"subitem_subject":"無毒変異TSST-1","subitem_subject_scheme":"Other"},{"subitem_subject":"経鼻粘膜免疫","subitem_subject_scheme":"Other"},{"subitem_subject":"黄色ブドウ球菌鼻腔内定着","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Protective Effect of Intranasal Vaccination with Nontoxic Mutant Toxic Shock Syndrome Toxin 1 against Staphylococcus Aureus Infections","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Protective Effect of Intranasal Vaccination with Nontoxic Mutant Toxic Shock Syndrome Toxin 1 against Staphylococcus Aureus Infections"}]},"item_type_id":"5","owner":"3","path":["642"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-08-19"},"publish_date":"2008-08-19","publish_status":"0","recid":"3607","relation_version_is_last":true,"title":["Protective Effect of Intranasal Vaccination with Nontoxic Mutant Toxic Shock Syndrome Toxin 1 against Staphylococcus Aureus Infections"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:53:28.999408+00:00"}