{"created":"2023-05-15T09:02:44.514235+00:00","id":3608,"links":{},"metadata":{"_buckets":{"deposit":"55f6cd78-8dd1-4048-abf3-a5930c719cfa"},"_deposit":{"created_by":3,"id":"3608","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3608"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003608","sets":["557:561:642"]},"author_link":["11662","11672","11463","11163","11447","11671","11153","11147","11451","11458","11161","11449","11661","11531","11456","11517","11664","11663","11155","11670","11524"],"item_5_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Tumor Necrosis Factor-α and Interferon-γ Synergistically Induce Expression of Retinoic Acid-Inducible Gene-I in Cultured Human Keratinocytes"}]},"item_5_alternative_title_22":{"attribute_name":"タイトル(ヨミ)","attribute_value_mlt":[{"subitem_alternative_title":"ヒト バイヨウ ケラチノサイト デ Tumor Necrosis Factor-αトInterferon-γ ワ ソウジョウテキ ニ Retinoic Acid-Inducible Gene-I ノ ハツゲン オ ゾウカサセル"}]},"item_5_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2/3/4","bibliographicPageEnd":"89","bibliographicPageStart":"83","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_5_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【背景】Retinoicacid-induciblegene-Ⅰ(RIG-Ⅰ)はRNA へリガーゼの一種であり,ウイルス感染により,細胞質内に蓄積する二重鎖RNAを認識する細胞内受容体である.【目的】Tumornecrosisfactor-α (TNF-α)とInterferon-㍗(IFN-γ) はそれぞれ表皮ケラチノサイトにおけるRIG-Ⅰの発現を増強させるが,その作用機序は不明である.本研究では.培養表皮ケラチノサイトであるHaCaT細胞において,RIG-Ⅰの発現に対するTNF-αとIFN-γの協調作用を検討した.【結果】RIG-ⅠのmRNAとタンパク発現量を半定量的RT-PCR法とウェスタンブロッティング法でそれぞれ解析した.その結果,TNF-aとIFN-γを同時添加した条件では,RIG-1タンパクとmRNA発現量が相乗的に増加していた.【結論】両サイトカインが相乗的にRIG-Ⅰの発現を上昇させたことから.2つのサイトカインは別々のシグナル伝達経路を介してRIG-Ⅰの発現を制御していると考えられた.","subitem_description_type":"Abstract"}]},"item_5_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59, 2008, p.83-89","subitem_description_type":"Other"}]},"item_5_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11663","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ミナカワ, サトコ"}]},{"nameIdentifiers":[{"nameIdentifier":"11664","nameIdentifierScheme":"WEKO"}],"names":[{"name":"キムラ, カズユキ"}]},{"nameIdentifiers":[{"nameIdentifier":"11161","nameIdentifierScheme":"WEKO"}],"names":[{"name":"マツザキ, ヤスシ"}]},{"nameIdentifiers":[{"nameIdentifier":"11163","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナカノ, ハジメ"}]},{"nameIdentifiers":[{"nameIdentifier":"11451","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イマイズミ, タダアツ"}]},{"nameIdentifiers":[{"nameIdentifier":"11456","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サトウ, ケイ"}]},{"nameIdentifiers":[{"nameIdentifier":"11524","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サワムラ, ダイスケ"}]}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11670","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100000089","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/100000089_ja.html"}],"names":[{"name":"Minakawa, Satoko"}]},{"nameIdentifiers":[{"nameIdentifier":"11671","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kimura, Kazuyuki"}]},{"nameIdentifiers":[{"nameIdentifier":"11672","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Matsuzaki, Yasushi"}]},{"nameIdentifiers":[{"nameIdentifier":"11147","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"269","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/269_ja.html"}],"names":[{"name":"Nakano, Hajime"}]},{"nameIdentifiers":[{"nameIdentifier":"11458","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"318","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/318_ja.html"}],"names":[{"name":"Imaizumi, Tadaatsu"}]},{"nameIdentifiers":[{"nameIdentifier":"11463","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Satoh, Kei"}]},{"nameIdentifiers":[{"nameIdentifier":"11517","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"268","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/268_ja.html"}],"names":[{"name":"Sawamura, Daisuke"}]}]},"item_5_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_5_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_5_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_5_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_5_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.3","subitem_subject_scheme":"NDC"}]},"item_5_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_5_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前大学大学院医学研究科皮膚科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科皮膚科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科皮膚科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科皮膚科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科附属脳神経血管病態研究施設脳血管病態学講座"},{"subitem_text_value":"弘前大学大学院医学研究科附属脳神経血管病態研究施設脳血管病態学講座"},{"subitem_text_value":"弘前大学大学院医学研究科皮膚科学講座"},{"subitem_text_value":"Department of Dermatology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Dermatology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Dermatology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Dermatology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Dermatology, Hirosaki University Graduate"}]},"item_5_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"皆川, 智子"}],"nameIdentifiers":[{"nameIdentifier":"11661","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村, 一之"}],"nameIdentifiers":[{"nameIdentifier":"11662","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松崎, 康司"}],"nameIdentifiers":[{"nameIdentifier":"11153","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中野, 創"}],"nameIdentifiers":[{"nameIdentifier":"11155","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今泉, 忠淳"}],"nameIdentifiers":[{"nameIdentifier":"11447","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"318","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/318_ja.html"}]},{"creatorNames":[{"creatorName":"佐藤, 敬"}],"nameIdentifiers":[{"nameIdentifier":"11449","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"澤村, 大輔"}],"nameIdentifiers":[{"nameIdentifier":"11531","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"268","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/268_ja.html"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"AN00211444_59_83.pdf","filesize":[{"value":"453.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00211444_59_83.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3608/files/AN00211444_59_83.pdf"},"version_id":"436cd9aa-705e-418c-8bf0-5e33d9ae94b0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ヒト培養ケラチノサイト","subitem_subject_scheme":"Other"},{"subitem_subject":"HaCaT細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"Tumor necrosis factor-α","subitem_subject_scheme":"Other"},{"subitem_subject":"Interferon-γ","subitem_subject_scheme":"Other"},{"subitem_subject":"Retinoic acid-inducible gene-I","subitem_subject_scheme":"Other"},{"subitem_subject":"Epidermal keratinocytes","subitem_subject_scheme":"Other"},{"subitem_subject":"HaCaT cell","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ヒト培養ケラチノサイトでTumor Necrosis Factor-αとInterferon-γはRetinoic Acid-Inducible Gene-Iの発現を増加させる","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト培養ケラチノサイトでTumor Necrosis Factor-αとInterferon-γはRetinoic Acid-Inducible Gene-Iの発現を増加させる"}]},"item_type_id":"5","owner":"3","path":["642"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-08-20"},"publish_date":"2008-08-20","publish_status":"0","recid":"3608","relation_version_is_last":true,"title":["ヒト培養ケラチノサイトでTumor Necrosis Factor-αとInterferon-γはRetinoic Acid-Inducible Gene-Iの発現を増加させる"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:27:09.766147+00:00"}