{"created":"2023-05-15T09:02:44.514235+00:00","id":3608,"links":{},"metadata":{"_buckets":{"deposit":"55f6cd78-8dd1-4048-abf3-a5930c719cfa"},"_deposit":{"created_by":3,"id":"3608","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3608"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003608","sets":["557:561:642"]},"author_link":["11662","11672","11463","11163","11447","11671","11153","11147","11451","11458","11161","11449","11661","11531","11456","11517","11664","11663","11155","11670","11524"],"item_5_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Tumor Necrosis Factor-α and Interferon-γ Synergistically Induce Expression of Retinoic Acid-Inducible Gene-I in Cultured Human Keratinocytes"}]},"item_5_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ヒト バイヨウ ケラチノサイト デ Tumor Necrosis Factor-αトInterferon-γ ワ ソウジョウテキ ニ Retinoic Acid-Inducible Gene-I ノ ハツゲン オ ゾウカサセル"}]},"item_5_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2/3/4","bibliographicPageEnd":"89","bibliographicPageStart":"83","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_5_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【背景】Retinoicacid-induciblegene-Ⅰ(RIG-Ⅰ)はRNA へリガーゼの一種であり,ウイルス感染により,細胞質内に蓄積する二重鎖RNAを認識する細胞内受容体である.【目的】Tumornecrosisfactor-α (TNF-α)とInterferon-㍗(IFN-γ) はそれぞれ表皮ケラチノサイトにおけるRIG-Ⅰの発現を増強させるが,その作用機序は不明である.本研究では.培養表皮ケラチノサイトであるHaCaT細胞において,RIG-Ⅰの発現に対するTNF-αとIFN-γの協調作用を検討した.【結果】RIG-ⅠのmRNAとタンパク発現量を半定量的RT-PCR法とウェスタンブロッティング法でそれぞれ解析した.その結果,TNF-aとIFN-γを同時添加した条件では,RIG-1タンパクとmRNA発現量が相乗的に増加していた.【結論】両サイトカインが相乗的にRIG-Ⅰの発現を上昇させたことから.2つのサイトカインは別々のシグナル伝達経路を介してRIG-Ⅰの発現を制御していると考えられた.","subitem_description_type":"Abstract"}]},"item_5_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59, 2008, p.83-89","subitem_description_type":"Other"}]},"item_5_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11663","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ミナカワ, サトコ"}]},{"nameIdentifiers":[{"nameIdentifier":"11664","nameIdentifierScheme":"WEKO"}],"names":[{"name":"キムラ, カズユキ"}]},{"nameIdentifiers":[{"nameIdentifier":"11161","nameIdentifierScheme":"WEKO"}],"names":[{"name":"マツザキ, 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Yasushi"}]},{"nameIdentifiers":[{"nameIdentifier":"11147","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"269","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/269_ja.html"}],"names":[{"name":"Nakano, Hajime"}]},{"nameIdentifiers":[{"nameIdentifier":"11458","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"318","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/318_ja.html"}],"names":[{"name":"Imaizumi, Tadaatsu"}]},{"nameIdentifiers":[{"nameIdentifier":"11463","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Satoh, Kei"}]},{"nameIdentifiers":[{"nameIdentifier":"11517","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"268","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/268_ja.html"}],"names":[{"name":"Sawamura, 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of Dermatology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Dermatology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Dermatology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Dermatology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Dermatology, Hirosaki University Graduate"}]},"item_5_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"皆川, 智子"}],"nameIdentifiers":[{"nameIdentifier":"11661","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村, 一之"}],"nameIdentifiers":[{"nameIdentifier":"11662","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松崎, 康司"}],"nameIdentifiers":[{"nameIdentifier":"11153","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中野, 創"}],"nameIdentifiers":[{"nameIdentifier":"11155","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"今泉, 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