{"created":"2023-05-15T09:02:44.558789+00:00","id":3609,"links":{},"metadata":{"_buckets":{"deposit":"eb570317-30f8-46d4-bfde-768099f6636c"},"_deposit":{"created_by":3,"id":"3609","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3609"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003609","sets":["557:561:642"]},"author_link":["11691","11678","11677","11686","11509","11191","11683","11696","11181","11679","11695","11688","11687","11690","11172","11680","11685","11109","11684","11697","11700","11498","11702","11692","11682","11701","11489","11103","11698","11097"],"item_5_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Transforming growth factor (TGF)-β Receptors are Suppressed in the Refracatory Cases with Ulcerative Colitis"}]},"item_5_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"チリョウ テイコウセイ カイヨウセイ ダイチョウエン ニオケル Transforming growth factor-β ジュヨウタイ ノ ハツゲン ヨクセイ"}]},"item_5_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2/3/4","bibliographicPageEnd":"97","bibliographicPageStart":"90","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_5_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"炎症性腸疾患は, 潰癌性大腸炎(UIcerativecolitis:UC), クローン病(Crohn'sdisease:CD) を含む原因不明の難治性炎症性腸疾患である. その病態には,Smadを介したTransforminggrowthfactor-β(TGF-β)シグナル伝達の異常が関与していることが報告されている.そこで, ステロイド治療抵抗性UC,ステロイド治療反応性UCのTGF-β受容体Ⅰ,Ⅱ型の蛋白量及びmRNA発現量について,腸管手術標本を用いWesternblottingとReal-timePCRで検討した. ステロイド治療反応性UCと比較しステロイド治療抵抗性UCで,TGF-β受容体I,Ⅱ型の蛋白量,mRNA発現量ともに有意な低下を認めた. このことから.遺伝子レベルでのTGF-β受容体の発現の低下がステロイド治療抵抗性UCの病態に関与している可能性が示唆された.","subitem_description_type":"Abstract"}]},"item_5_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59, 2008, p.90-97","subitem_description_type":"Other"}]},"item_5_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11685","nameIdentifierScheme":"WEKO"}],"names":[{"name":"シマヤ, コウジ"}]},{"nameIdentifiers":[{"nameIdentifier":"11686","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イシグロ, ヨウ"}]},{"nameIdentifiers":[{"nameIdentifier":"11687","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カワグチ, ショウゴ"}]},{"nameIdentifiers":[{"nameIdentifier":"11688","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サトウ, ユウキ"}]},{"nameIdentifiers":[{"nameIdentifier":"11498","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヒラガ, ヒロト"}]},{"nameIdentifiers":[{"nameIdentifier":"11690","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヤマグチ, 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of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, 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factor-β受容体の発現抑制"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:06:23.969939+00:00"}