{"created":"2023-05-15T09:02:44.735438+00:00","id":3613,"links":{},"metadata":{"_buckets":{"deposit":"91be1374-e6d0-403d-be8f-d5336a6cf47f"},"_deposit":{"created_by":3,"id":"3613","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3613"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003613","sets":["557:561:642"]},"author_link":["11773","11769","11778","10950","10960","11777","11772","11779","11771","11768","11776","11766","11767","10955","13018"],"item_5_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ヒアルロン酸合成抑制剤である4-メチルウンベリフェロンおよび4-メチルウンベリフェロン誘導体である4-メチルエスクレチンの胸膜悪性中皮腫に対するヒアルロン酸合成阻害効果の検討"}]},"item_5_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ヒアルロンサン ゴウセイ ヨクセイザイ デアル 4-メチルウンベリフェロン オヨビ 4-メチルウンベリフェロン ユウドウタイ デアル 4-メチルエスクレチン ノ キョウマク アクセイ チュウヒシュ ニ タイスル ヒアルロンサン ゴウセイ ソガイ コウカ ノ ケントウ"}]},"item_5_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2/3/4","bibliographicPageEnd":"127","bibliographicPageStart":"118","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_5_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_5_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hyaluronan (HA) is a major component of the pericellular matrix, and is implicated in cell adhesion, invasion. and tumor metastasis. We have reported that 4-methylumbelliferone (MU)  inhibits HA synthesis by cultured skin fibroblasts, melanoma cells, and pancreatic cancer cells. We focused in the present study, on mesothelioma which has an extremely poor prognosis, and in which no effective therapy has yet been established. We investigated dealing with this neoplasm whether MU and 4-methylesculetin (ME), a MU derivative, are able to inhibit HA synthesis by the mesothelioma cell line NCI-H2052. MU inhibited HA synthesis by about 20%, and ME by about 40%, in comparison with the control group. MU inhibited the adhesion of NCI-H2052 cells by about 30%, and ME by about 50%, compared with the untreated control. MU inhibited cell locomotion by about 30%. and ME by about 40%. It is suggested through these results suggest that MU and ME inhibit HA synthesis. adhesion, and locomotion by human mesothelioma cells and weaken their pericellular matrix, and that the inhibitory effect of ME on HA synthesis is stronger than that of MU. It is presumed that both MU and ME may have potential as new therapeutic or prophylactic medicines against mesothelioma.","subitem_description_type":"Abstract"}]},"item_5_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59, 2008, p.118-127","subitem_description_type":"Other"}]},"item_5_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11771","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナカイ, マコト"}]},{"nameIdentifiers":[{"nameIdentifier":"11772","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヨシハラ, シュウイチ"}]},{"nameIdentifiers":[{"nameIdentifier":"11773","nameIdentifierScheme":"WEKO"}],"names":[{"name":"モロハシ, ハジメ"}]},{"nameIdentifiers":[{"nameIdentifier":"13018","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イシド, ケイノスケ"}]},{"nameIdentifiers":[{"nameIdentifier":"10955","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ササキ, ムツオ"}]}]},"item_5_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11776","nameIdentifierScheme":"WEKO"}],"names":[{"name":"中井, 款"}]},{"nameIdentifiers":[{"nameIdentifier":"11777","nameIdentifierScheme":"WEKO"}],"names":[{"name":"吉原, 秀一"}]},{"nameIdentifiers":[{"nameIdentifier":"11778","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100000348","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/100000348_ja.html"}],"names":[{"name":"諸橋, 一"}]},{"nameIdentifiers":[{"nameIdentifier":"11779","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"194","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/194_ja.html"}],"names":[{"name":"石戸, 圭之輔"}]},{"nameIdentifiers":[{"nameIdentifier":"10950","nameIdentifierScheme":"WEKO"}],"names":[{"name":"佐々木, 睦男"}]}]},"item_5_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_5_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_5_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_5_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_5_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"494.2","subitem_subject_scheme":"NDC"}]},"item_5_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"外科系臨床医学","subitem_subject_scheme":"Other"}]},"item_5_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Digestive Surgery, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Digestive Surgery, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Digestive Surgery, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Digestive Surgery, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Digestive Surgery, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"弘前大学大学院医学研究科消化器外科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科消化器外科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科消化器外科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科消化器外科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科消化器外科学講座"}]},"item_5_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakai, Makoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshihara, Shuichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morohashi, Hajime"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishido, Keinosuke"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Sasaki, Mutsuo"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"AN00211444_59_118.pdf","filesize":[{"value":"990.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00211444_59_118.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3613/files/AN00211444_59_118.pdf"},"version_id":"b0df3a18-5217-4f8e-b63f-ec87c291a37a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"hyaluronan","subitem_subject_scheme":"Other"},{"subitem_subject":"mesothelioma","subitem_subject_scheme":"Other"},{"subitem_subject":"4-methylumbelliferone","subitem_subject_scheme":"Other"},{"subitem_subject":"4-methylesculetin","subitem_subject_scheme":"Other"},{"subitem_subject":"NCI-H2052","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒアルロン酸","subitem_subject_scheme":"Other"},{"subitem_subject":"悪性中皮種","subitem_subject_scheme":"Other"},{"subitem_subject":"4-メチルウンベリフェロン","subitem_subject_scheme":"Other"},{"subitem_subject":"4-メチルエスクレチン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of Hyaluronan Synthase Inhibitors, 4-Methylumbelliferone and 4-Methylesculetin on Human Pleural Malignant Mesothelioma Cells (NCI-H2052)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Hyaluronan Synthase Inhibitors, 4-Methylumbelliferone and 4-Methylesculetin on Human Pleural Malignant Mesothelioma Cells (NCI-H2052)"}]},"item_type_id":"5","owner":"3","path":["642"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-08-21"},"publish_date":"2008-08-21","publish_status":"0","recid":"3613","relation_version_is_last":true,"title":["Effects of Hyaluronan Synthase Inhibitors, 4-Methylumbelliferone and 4-Methylesculetin on Human Pleural Malignant Mesothelioma Cells (NCI-H2052)"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:11:34.306579+00:00"}