{"created":"2023-05-15T09:02:44.897660+00:00","id":3616,"links":{},"metadata":{"_buckets":{"deposit":"25fdc134-1efb-42d4-9a11-c9306b033b2f"},"_deposit":{"created_by":3,"id":"3616","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3616"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003616","sets":["557:561:643"]},"author_link":["11798","11796","11797"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S11","bibliographicPageStart":"S1","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Responses to stimuli in cellar level are diverse and such hierarchical as secretion of stored factors,\nsynthesis of lipid mediators and protein synthesis through genomic transcription. However, how can the cells\nrespond in the case of necrosis? Recently a characteristic intranuclear protein, high-mobility group box 1 protein\n（HMGB1） is released from necrotic cells. The protein is an abundant nuclear protein with a dual function\nboth inside and outside the cells. In physiological state, HMGB1 is present in the nucleus, and binds to DNA,\nplaying a variety of crucial functions, including transcription and keeping the characteristic DNA architecture.\nHowever, the protein is released to extracellular space from most of necrotic cells, activated macrophages and\ndendritic cells. Out of the cells, HMGB1 acts as a signal of tissue damage and can promote infl ammation, immune\nresponses, and results tissue regeneration. During sepsis and/or disseminated intravascular coagulation （DIC）,\nhowever, massive accumulation of HMGB1 in the systemic circulation will cause multiple organ failure （MOF）\nand subsequent lethal outcome. Thus HMGB1 in the systemic circulation has been considered as a lethal\nmediator of sepsis, and a promising therapeutic target for sepsis. Recently we identified that thrombomodulin\n（TM）, a natural anticoagulant glycoprotein expressed on the surface of endothelial cells, plays an important\nrole in sequestering HMGB1. TM may prevent HMGB1 from reaching remote organs, thereby restricting\nthe spectrum of HMGB1 action in the site of injury. Here we review recent progress made in defining the\nphysiological and pathological roles of HMGB1 and therapeutic strategies aimed at blocking circulatory HMGB1.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59(Suppl.), 2007, p.S1-S11","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Laboratory and Vascular Medicine,Kagoshima University Graduate School of Medical and Dental Sciences"},{"subitem_text_value":"Department of Laboratory and Vascular Medicine,Kagoshima University Graduate School of Medical and Dental Sciences"},{"subitem_text_value":"Department of Laboratory and Vascular Medicine,Kagoshima University Graduate School of Medical and Dental Sciences"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Maruyama, Ikuro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hashiguchi, Teruto"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_59_S1.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_59_S1.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3616/files/HirosakiMedJ_59_S1.pdf"},"version_id":"950f9001-584a-4648-b6e6-217d43d22aea"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"sepsis","subitem_subject_scheme":"Other"},{"subitem_subject":"disseminated intravascular coagulation(DIC)","subitem_subject_scheme":"Other"},{"subitem_subject":"thrombomodulin","subitem_subject_scheme":"Other"},{"subitem_subject":"alarmin","subitem_subject_scheme":"Other"},{"subitem_subject":"highmobility group box 1 (HMGB1)","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Newly identifi ed message for rescue and repair from necrotic cell: Biology and clinical relevance of“endokine, HMGB1”","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Newly identifi ed message for rescue and repair from necrotic cell: Biology and clinical relevance of“endokine, HMGB1”"}]},"item_type_id":"3","owner":"3","path":["643"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-18"},"publish_date":"2009-09-18","publish_status":"0","recid":"3616","relation_version_is_last":true,"title":["Newly identifi ed message for rescue and repair from necrotic cell: Biology and clinical relevance of“endokine, HMGB1”"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T06:43:09.021624+00:00"}