{"created":"2023-05-15T09:02:44.962573+00:00","id":3617,"links":{},"metadata":{"_buckets":{"deposit":"43036a21-f432-4672-8a5e-b5598c82fdf9"},"_deposit":{"created_by":3,"id":"3617","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3617"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003617","sets":["557:561:643"]},"author_link":["11799"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S18","bibliographicPageStart":"S12","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Human parvovirus B19 （B19） is single stranded DNA virus, that causes erythema infectinosum in infant\nand/or acute onset polyarthritis in adult. We present the evidence showing the role of B19 on the etiopathogy of\nrheumatoid arthritis（ RA）.（ 1） B19 DNA could be frequently amplifi ed in the samples from rheumatoid joints. The\ndetection B19 RNA and B19 protein VP1 was specific for RA, and positive at T cells, B cells, macrophages and\nfollicular dendritic cells in rheumatoid synovium. （ 2） B19 infection or transduction of B19 NS1gene caused TNFα,\nIL-6 and IL-8 production through activating AP1 and AP2 in macrophages or macrophage celll line U937. We also\nfound Ku80 as a novel receptor for B19 on T cells, macrophages or erythroblasts. B19 used clathrin on the surface at\ntheir cell entry and caused enhanced actin polymerization, resulting in the migration of T cells. （ 3） B19-transgenic\nmice became susceptible to type II collagen-induced polyarthritis that is a model of RA. We also experienced 12\ncases who developed RA after acute B19 infection. （ 4） Half of RA cases had a defective neutralizing ability to B19.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59(Suppl.), 2007, p.S12-S18","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.8","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Rheumatology and Hematology, Tohoku University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sasaki, Takeshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_59_S12.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_59_S12.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3617/files/HirosakiMedJ_59_S12.pdf"},"version_id":"ce804ed5-c64c-427b-80ec-ef72bf43a068"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"human parvovirus B19","subitem_subject_scheme":"Other"},{"subitem_subject":"rheumatoid arthritis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Human parvovirus B19 and rheumatoid arthritis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Human parvovirus B19 and rheumatoid arthritis"}]},"item_type_id":"3","owner":"3","path":["643"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-18"},"publish_date":"2009-09-18","publish_status":"0","recid":"3617","relation_version_is_last":true,"title":["Human parvovirus B19 and rheumatoid arthritis"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T06:43:06.988340+00:00"}