{"created":"2023-05-15T09:02:45.027813+00:00","id":3618,"links":{},"metadata":{"_buckets":{"deposit":"38052244-fca9-4f7c-bbe4-bbc4ad38e8bd"},"_deposit":{"created_by":3,"id":"3618","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3618"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003618","sets":["557:561:643"]},"author_link":["11802","11805","11801","11800","11803","11804","11806"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S25","bibliographicPageStart":"S19","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Human infl uenza virus causes an annual epidemic infection. After infl uenza virus infection in the airway,\ninfection sometimes spreads with severe neurologic complication and multiple organ failure, resulting in high\nmortality. In the process of viral spread from the lungs to other organs, signifi cant up-regulated trpsin was observed\nin various organs. Up-regulated trypsin eff ectively converted precursor of the viral envelope hemagglutinin（ HA） into\nHA1 and HA2 subunits. The proteolytic activation of HA is a prerequisite for virus multiplication. Administration of\nthe inhibitors of trypsin as new approaches for the treatment of infl uenza virus infection eff ectively suppressed viral\nmultiplication. Almost vaccines for infl uenza virus infection are administered i.m. or s.c., which induce IgG-mediated\nprotection in the systemic immune compartment, but this immunization off ers insuffi cient protection on the mucosal\nsurface at the initial site of viral multiplication. To improve protective mucosal immunity, intranasal vaccination\nhas been studied. The powerful mucosal adjuvants reported are toxin based, such as cholera toxin and Escherichia\ncoli heat-labile toxin, but these enterotoxins cause severe side eff ects. We recently found natural mucosal adjuvant,\npulmonary surfactant, in the lungs. Intranasal administration of infl uenza vaccine combined with Surfacten, a modifi ed\npulmonary surfactant free of antigenic c-type lectins, induced high protective mucosal immunity in the airway and\nsystemic immune responses in the blood, the effi cacy of both protective immunities by Surfacten being equivalent to\nthose by cholera toxin. In this symposium, we reported the eff ects of Surfacten on mucosal and systemic immunities.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59(Suppl.), 2007, p.S19-S25","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.8","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima"},{"subitem_text_value":"Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima"},{"subitem_text_value":"Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima"},{"subitem_text_value":"Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima"},{"subitem_text_value":"Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima"},{"subitem_text_value":"Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima"},{"subitem_text_value":"Division of Enzyme Chemistry, Institute for Enzyme Research, The University of Tokushima"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kido, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mizuno, Dai"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Le, Quang Trong"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chida, Junji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okumura, Yuushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yano, Mihiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_59_S19.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_59_S19.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3618/files/HirosakiMedJ_59_S19.pdf"},"version_id":"8bbdabfe-8c91-4ea8-94da-4a39e1a45c8d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"influenza virus","subitem_subject_scheme":"Other"},{"subitem_subject":"mucosal immunization","subitem_subject_scheme":"Other"},{"subitem_subject":"pulmonary surfactant","subitem_subject_scheme":"Other"},{"subitem_subject":"ectopic trypsin","subitem_subject_scheme":"Other"},{"subitem_subject":"influenzaassociated encephalopathy","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"New approaches for prevention and treatment of infl uenza virus infection by an enhancement of mucosal immunization and suppression of protease expression","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"New approaches for prevention and treatment of infl uenza virus infection by an enhancement of mucosal immunization and suppression of protease expression"}]},"item_type_id":"3","owner":"3","path":["643"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-18"},"publish_date":"2009-09-18","publish_status":"0","recid":"3618","relation_version_is_last":true,"title":["New approaches for prevention and treatment of infl uenza virus infection by an enhancement of mucosal immunization and suppression of protease expression"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T06:43:06.221550+00:00"}