@article{oai:hirosaki.repo.nii.ac.jp:00003619,
 author = {Kurachi, Makoto and Kakimi, Kazuhiro and Ueha, Satoshi and Matsushima, Kouji},
 issue = {Supplement},
 journal = {弘前医学},
 month = {Nov},
 note = {application/pdf, Memory CD8+ T cells generated during an immune response are long-lived and self-renewing, off ering
enhanced host protection against re-infection. However, how an antigen-specific population of memory T cells is
maintained throughout repetitive infections over potentially a lifetime is not known. Here we review the generation
and maintenance of antigen-specifi c CD8+ T cells and introduce our recent data showing dynamic turnover of an
antigen-specific memory T cell population during repeated antigen challenge in vivo. We demonstrated that a
primary response potentially occurs upon every recall response and fi nd that the skewed T-cell receptor （TCR）
repertoire of pre-existing memory T cells is partly corrected by diversity in a newly formed （primary） population.
Importantly, memory T cells generated in a more recent antigen encounter expand more vigorously in a subsequent
recall response. A primary response during re-challenge therefore restores both the TCR diversity and proliferative
potential of the memory T cell population. These findings indicate that memory T cell populations evolve over
multiple challenges, favoring memory T cells generated in more recent encounters, and suggest that these primary
populations have essential roles in the perpetuation of antigen-specifi c T cell populations., 弘前医学. 59(Suppl.), 2007, p.S26-S34},
 pages = {S26--S34},
 title = {Rejuvenation of T cell memory},
 volume = {59},
 year = {2007}
}