@article{oai:hirosaki.repo.nii.ac.jp:00003620,
 author = {Ohteki, Toshiaki and Kuwajima, Seiichi},
 issue = {Supplement},
 journal = {弘前医学},
 month = {Nov},
 note = {application/pdf, Unmethylated CpG oligodeoxynucleotides （CpG） prevalent in bacteria and DNA viruses bind Toll-like
receptor（ TLR） 9 and directly stimulate DCs, thereby activating the innate and adaptive immune responses. CpG is
potentially a powerful reagent for protective immunity against infection by a wide variety of pathogens, for cancer
and allergy therapies, and for the development of prophylactic and therapeutic vaccines. Here we investigated the
role of interleukin （IL）-15 in the activation of CpG-induced immune responses. We show that upon CpG-priming,
both wild-type（ WT） and NK cell-depleted WT mice produce interleukin（ IL）-12 p70 and become resistant to a lethal
dose of Listeria monocytogenes（ LM）, whereas IL-15-/- mice impair IL-12 p70 production and succumb to the infection.
Notably, CpG-stimulated conventional dendritic cells （cDCs） are the major producer of both IL-15 and IL-12 p70,
but cDCs do not produce IL-12 in the absence of plasmacytoid DCs（ pDCs） in vivo. Importantly, cDC-derived IL-15
induces CD40 expression on cDCs, which interacts with CD40 ligand on pDCs, leading to CD40 cross-linking and IL-12
production. Collectively, these fi ndings show that IL-15-dependent cross-talk between cDCs and pDCs is essential for
CpG-induced immune activation（ recently published in Nat Immunol 2006;7:740-6）, 弘前医学. 59(Suppl.), 2007, p.S35-S42},
 pages = {S35--S42},
 title = {IL-15-dependent cross-talk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation},
 volume = {59},
 year = {2007}
}