{"created":"2023-05-15T09:02:45.161406+00:00","id":3620,"links":{},"metadata":{"_buckets":{"deposit":"623aaca5-2215-4573-a1e5-8af1765f83e3"},"_deposit":{"created_by":3,"id":"3620","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3620"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003620","sets":["557:561:643"]},"author_link":["11812","11811"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S42","bibliographicPageStart":"S35","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Unmethylated CpG oligodeoxynucleotides （CpG） prevalent in bacteria and DNA viruses bind Toll-like\nreceptor（ TLR） 9 and directly stimulate DCs, thereby activating the innate and adaptive immune responses. CpG is\npotentially a powerful reagent for protective immunity against infection by a wide variety of pathogens, for cancer\nand allergy therapies, and for the development of prophylactic and therapeutic vaccines. Here we investigated the\nrole of interleukin （IL）-15 in the activation of CpG-induced immune responses. We show that upon CpG-priming,\nboth wild-type（ WT） and NK cell-depleted WT mice produce interleukin（ IL）-12 p70 and become resistant to a lethal\ndose of Listeria monocytogenes（ LM）, whereas IL-15-/- mice impair IL-12 p70 production and succumb to the infection.\nNotably, CpG-stimulated conventional dendritic cells （cDCs） are the major producer of both IL-15 and IL-12 p70,\nbut cDCs do not produce IL-12 in the absence of plasmacytoid DCs（ pDCs） in vivo. Importantly, cDC-derived IL-15\ninduces CD40 expression on cDCs, which interacts with CD40 ligand on pDCs, leading to CD40 cross-linking and IL-12\nproduction. Collectively, these fi ndings show that IL-15-dependent cross-talk between cDCs and pDCs is essential for\nCpG-induced immune activation（ recently published in Nat Immunol 2006;7:740-6）","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59(Suppl.), 2007, p.S35-S42","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.8","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Immunology, Akita University, Graduate School of Medicine"},{"subitem_text_value":"Department of Immunology, Akita University, Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ohteki, Toshiaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kuwajima, Seiichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_59_S35.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_59_S35.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3620/files/HirosakiMedJ_59_S35.pdf"},"version_id":"f2092b97-8c28-4581-825f-db79776c270d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"innate immunity","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-12","subitem_subject_scheme":"Other"},{"subitem_subject":"TLR9","subitem_subject_scheme":"Other"},{"subitem_subject":"Listeria monocytogenes","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"IL-15-dependent cross-talk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"IL-15-dependent cross-talk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation"}]},"item_type_id":"3","owner":"3","path":["643"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-18"},"publish_date":"2009-09-18","publish_status":"0","recid":"3620","relation_version_is_last":true,"title":["IL-15-dependent cross-talk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T06:42:55.173606+00:00"}