{"created":"2023-05-15T09:02:45.228076+00:00","id":3621,"links":{},"metadata":{"_buckets":{"deposit":"269bee02-cfc1-442b-b0ad-5cfdb4df1877"},"_deposit":{"created_by":3,"id":"3621","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3621"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003621","sets":["557:561:643"]},"author_link":["11814","11816","11813","11815"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S51","bibliographicPageStart":"S43","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Double-stranded （ds）RNA-recognition receptors reside in the cytoplasm and membranes of cells. These\nreceptors are implicated in the differential screening of microbes by the host. Myeloid dendritic cells （mDCs）\nrecognize and respond to polyI:C, an analog of dsRNA, by endosomal TLR3 and cytoplasmic MDA5. NK cells are\ninduced in vivo by the administration of polyI:C to mice and in vitro are reciprocally activated by mDCs, although the\nmolecular mechanisms as yet undetermined. Here, we show that the TLR adapter TICAM-1 （TRIF） participates in\nmDC-derived antitumor NK activation. In a syngeneic mouse tumor implant model, intraperitoneal administration of\npolyI:C led to the retardation of tumor growth, which eff ect relied largely on NK activation. This NK-dependent tumor\nregression did not occur in TICAM-1-/- or IFNAR-/- mice, while a normal NK antitumor response was induced in PKR-/-,\nMyD88-/-, IFN-β-/- and wild-type mice. IFNAR was a prerequisite for the induction of IFN-α/β and TLR3. The lack\nof TICAM-1 did not aff ect IFN production but resulted in unresponsiveness to IL-12 production, mDC maturation and\npolyI:C-mediated antitumor activity. This NK activation required NK-mDC contact in in vitro transwell analysis. NKantitumor\nactivity was successfully introduced into tumor-implanted mice by transferring mDCs expressing TICAM-1.\nImplanted tumor growth in IFNAR-/- mice was retarded by adoptively transferring polyI:C-treated TICACM-1-positive\nmDCs but not TICAM-1-/- mDCs. Thus, TICAM-1 rather than MDA5 in mDCs critically facilitated mDC-NK contact\nand activation of antitumor NK, resulting in the regression of low MHC-expressing tumors","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59(Suppl.), 2007, p.S43-S51","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"494.5","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"外科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine"},{"subitem_text_value":"Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine"},{"subitem_text_value":"Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine"},{"subitem_text_value":"Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Seya, Tsukasa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumoto, Misako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ebihara, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akazawa, Takashi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_59_S43.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_59_S43.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3621/files/HirosakiMedJ_59_S43.pdf"},"version_id":"a73ba67e-54a5-47ec-9d1c-1cf3d04d6f9d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"natural killer cells (NK)","subitem_subject_scheme":"Other"},{"subitem_subject":"dendritic cells","subitem_subject_scheme":"Other"},{"subitem_subject":"Toll-like receptor(TLR)","subitem_subject_scheme":"Other"},{"subitem_subject":"TICAM-1(TRIF)","subitem_subject_scheme":"Other"},{"subitem_subject":"adjuvant","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"NK-activating dendritic cells are elicited by stimulation with Toll-like receptor 3","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"NK-activating dendritic cells are elicited by stimulation with Toll-like receptor 3"}]},"item_type_id":"3","owner":"3","path":["643"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-18"},"publish_date":"2009-09-18","publish_status":"0","recid":"3621","relation_version_is_last":true,"title":["NK-activating dendritic cells are elicited by stimulation with Toll-like receptor 3"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T06:42:49.922898+00:00"}