@article{oai:hirosaki.repo.nii.ac.jp:00003626,
 author = {Warner, Margaret and Gustafsson, Jan-Åke},
 issue = {Supplement},
 journal = {弘前医学},
 month = {Nov},
 note = {application/pdf, Estrogen has distinct functions in the immune system where it acts via ERα and HERβ respectively.
Surprisingly, the defects in the immune system which develop in the absence of either ERα or ERβ are quite
distinct from what develops in the absence of estrogen. We have found by studying mice in which either or both
estrogen receptors have been inactivated that the two estrogen receptors play distinct roles in the immune system.
Loss of ERβ leads to chronic myeloid leukemia and loss of ERα leads to autoimmune disease. In mice which cannot
synthesize estrogen there is also autoimmune disease resembling Sjögren’s Syndrome. We plan to study these mice
further with the aim of fi nding the exact sites of action of the two receptors in the immune system and by using
specifi c ligands for ERα. or ERβ to examine how specifi c parts of the immune system can be modifi ed. These studies
should lead to improved treatment of patients with diseases of the immune system., 弘前医学. 59(Suppl.), 2007, p.S77-S81},
 pages = {S77--S81},
 title = {Estrogen receptors in diseases of the immune system},
 volume = {59},
 year = {2007}
}