{"created":"2023-05-15T09:02:45.556308+00:00","id":3626,"links":{},"metadata":{"_buckets":{"deposit":"557b56e7-8a68-429b-835a-58770f189af2"},"_deposit":{"created_by":3,"id":"3626","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3626"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003626","sets":["557:561:643"]},"author_link":["11831","11832"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S81","bibliographicPageStart":"S77","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Estrogen has distinct functions in the immune system where it acts via ERα and HERβ respectively.\nSurprisingly, the defects in the immune system which develop in the absence of either ERα or ERβ are quite\ndistinct from what develops in the absence of estrogen. We have found by studying mice in which either or both\nestrogen receptors have been inactivated that the two estrogen receptors play distinct roles in the immune system.\nLoss of ERβ leads to chronic myeloid leukemia and loss of ERα leads to autoimmune disease. In mice which cannot\nsynthesize estrogen there is also autoimmune disease resembling Sjögren’s Syndrome. We plan to study these mice\nfurther with the aim of fi nding the exact sites of action of the two receptors in the immune system and by using\nspecifi c ligands for ERα. or ERβ to examine how specifi c parts of the immune system can be modifi ed. These studies\nshould lead to improved treatment of patients with diseases of the immune system.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59(Suppl.), 2007, p.S77-S81","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.8","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Biosciences and Nutrition, Novum, Karolinska University Hospital, Huddinge, Karolinska Institutet"},{"subitem_text_value":"Department of Biosciences and Nutrition, Novum, Karolinska University Hospital, Huddinge, Karolinska Institutet"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Warner, Margaret"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Gustafsson, Jan-Åke"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_59_S77.pdf","filesize":[{"value":"96.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_59_S77.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3626/files/HirosakiMedJ_59_S77.pdf"},"version_id":"3730b646-91a8-4597-b671-f4f35212f797"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Estrogen receptors in diseases of the immune system","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Estrogen receptors in diseases of the immune system"}]},"item_type_id":"3","owner":"3","path":["643"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-18"},"publish_date":"2009-09-18","publish_status":"0","recid":"3626","relation_version_is_last":true,"title":["Estrogen receptors in diseases of the immune system"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T06:42:49.232200+00:00"}