@article{oai:hirosaki.repo.nii.ac.jp:00003629,
 author = {Yagihashi, Soroku and Yamagishi, Shin-Ichiro and Mizukami, Hiroki and Wada, Ryuichi},
 issue = {Supplement},
 journal = {弘前医学},
 month = {Nov},
 note = {application/pdf, Accumulating evidence supports that proinflammatory processes are implicated in the establishment
of characteristic pathology in diabetic vascular and neurological complications. Altered cellular signaling during
inflammatory processes is a new target for the treatment of diabetic complications and there appear to be some
attempts to explore the eff ects of thiazolidinedione, a ligand of peroxisome proliferating activator receptor（ PPAR）-γ
for not only the treatment of diabetes itself but for the application to diabetic complications. We therefore explored the
eff ects of PPAR-γ agonist, pioglitazone, on the experimental model of diabetic neuropathy. We found that pioglitazone
signifi cantly improved nerve conduction velocities and depressed protein kinase C activity. This is a new area for the
exploration of eff ective treatment of diabetic complications that pose a considerable socioeconomic burden in the current
world., 弘前医学. 59(Suppl.), 2007, p.S101-S108},
 pages = {S101--S108},
 title = {Implication of proinfl ammatory reactions in pathogenesis of diabetic microvascular complications},
 volume = {59},
 year = {2007}
}