{"created":"2023-05-15T09:02:45.751631+00:00","id":3629,"links":{},"metadata":{"_buckets":{"deposit":"44a50883-b1fd-40ed-931f-683a1ee1a904"},"_deposit":{"created_by":3,"id":"3629","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3629"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003629","sets":["557:561:643"]},"author_link":["11844","11842","11845","11843"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S108","bibliographicPageStart":"S101","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Accumulating evidence supports that proinflammatory processes are implicated in the establishment\nof characteristic pathology in diabetic vascular and neurological complications. Altered cellular signaling during\ninflammatory processes is a new target for the treatment of diabetic complications and there appear to be some\nattempts to explore the eff ects of thiazolidinedione, a ligand of peroxisome proliferating activator receptor（ PPAR）-γ\nfor not only the treatment of diabetes itself but for the application to diabetic complications. We therefore explored the\neff ects of PPAR-γ agonist, pioglitazone, on the experimental model of diabetic neuropathy. We found that pioglitazone\nsignifi cantly improved nerve conduction velocities and depressed protein kinase C activity. This is a new area for the\nexploration of eff ective treatment of diabetic complications that pose a considerable socioeconomic burden in the current\nworld.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59(Suppl.), 2007, p.S101-S108","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Molecular Pathology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Molecular Pathology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Molecular Pathology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Molecular Pathology, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yagihashi, Soroku"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamagishi, Shin-Ichiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mizukami, Hiroki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Wada, Ryuichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_59_S101.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_59_S101.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3629/files/HirosakiMedJ_59_S101.pdf"},"version_id":"295898f6-4310-4e1f-9e47-6aad5703b771"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"inflammation","subitem_subject_scheme":"Other"},{"subitem_subject":"diabetes","subitem_subject_scheme":"Other"},{"subitem_subject":"vasculopathy","subitem_subject_scheme":"Other"},{"subitem_subject":"neuropathy","subitem_subject_scheme":"Other"},{"subitem_subject":"PPAR-γ","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Implication of proinfl ammatory reactions in pathogenesis of diabetic microvascular complications","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Implication of proinfl ammatory reactions in pathogenesis of diabetic microvascular complications"}]},"item_type_id":"3","owner":"3","path":["643"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-18"},"publish_date":"2009-09-18","publish_status":"0","recid":"3629","relation_version_is_last":true,"title":["Implication of proinfl ammatory reactions in pathogenesis of diabetic microvascular complications"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:55:13.521530+00:00"}