{"created":"2023-05-15T09:02:45.816237+00:00","id":3630,"links":{},"metadata":{"_buckets":{"deposit":"26cee91a-8526-492c-a2b9-10e3aac9afc1"},"_deposit":{"created_by":3,"id":"3630","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3630"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003630","sets":["557:561:643"]},"author_link":["11846","11848","11847"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S118","bibliographicPageStart":"S109","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Clinically opioids are immunomodulatory where a general depression is reported. In addition, immune\ncells carry endogenous opioid peptides to sites of inflammation where opioid receptors on peripheral nerves are\nupregulated. Release of these endogenous opioids produces a degree of analgesia and completes the neuroimmune axis.\nThe expression of opioid receptors on immune cells that deliver these opioid peptides, is contentious and is the basis of\nthis short review. There are several papers reporting expression of opioid receptors on peripheral blood mononuclear\ncells （PBMCs） using a variety of in vitro biochemical/pharmacological techniques. Equally there are studies failing\nto detect these receptors. We have recently undertaken a detailed volunteer study to determine the expression of\nclassical naloxone sensitive MOP, DOP and KOP and non-classical naloxone insensitive NOP receptors. We initially\nfocused our attention on the MOP receptor as the main clinical analgesic target. Using radioligand binding, FACS\nwith opioid receptor antibodies and PCR we have failed to detect all classical opioid receptors. In contrast, using PCR\ntechniques the non-classical NOP receptor is present in all volunteer samples examined along with its endogenous\npeptide ligand nociceptin/orphanin F/Q （N/OFQ）. As both the peptide （N/OFQ） and receptor （NOP） are present\nwe suggest that there may be a feedback loop such that peripherally delivered N/OFQ（ to infl ammatory site） would\nproduce both a classical analgesic response and then feedback to modulate PMBC function. The nature of that function\nremains to be determined but could include release of further N/OFQ, activation of other immune cells or chemotaxis.\nOpioids have been used by man for centuries for the relief of pain. Morphine is the most widely used opioid in the\nclinic and is considered the gold standard to which all others are compared. In addition to producing analgesia, opioid\nadministration also produces other eff ects including; respiratory depression, gastrointestinal-inhibition, tolerance and\ndependence and immunomodulationbasic summaries see1-4）. Patients receiving long term opioid treatment display signs of\nimmunodepression; it has been suggested that this may occur either as a direct eff ect of opioids on circulating immune\ncells or via a central action （see below）. Neuronal opioid receptors are up-regulated in peripheral infl ammation and\nStein and colleagues（ in particular） have shown that release of these endogenous opioids from circulating immune cells\nproduces a degree of analgesia and complete the neuroimmune axis5）, i.e., immunomodulation of neuronal activity. The\nexpression of opioid receptors on the circulating immune cells that deliver these opioid peptides remains unclear and is\nthe focus of this short review.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59(Suppl.), 2007, p.S109-S118","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"492.3","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Cardiovascular Sciences (Pharmacology and Therapeutics Group), Division of Anaesthesia, Critical Care and Pain Management, University of Leicester"},{"subitem_text_value":"Department of Cardiovascular Sciences (Pharmacology and Therapeutics Group), Division of Anaesthesia, Critical Care and Pain Management, University of Leicester"},{"subitem_text_value":"Department of Cardiovascular Sciences (Pharmacology and Therapeutics Group), Division of Anaesthesia, Critical Care and Pain Management, University of Leicester"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Lambert, David G."}],"nameIdentifiers":[{"nameIdentifier":"11846","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Williams, John P."}],"nameIdentifiers":[{"nameIdentifier":"11847","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Thompson, Jonathan P."}],"nameIdentifiers":[{"nameIdentifier":"11848","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_59_S109.pdf","filesize":[{"value":"324.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_59_S109.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3630/files/HirosakiMedJ_59_S109.pdf"},"version_id":"d5e33029-a761-4991-beaf-1c9cad6bb19c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"opioids","subitem_subject_scheme":"Other"},{"subitem_subject":"immunomodulation","subitem_subject_scheme":"Other"},{"subitem_subject":"peripheral blood mononuclear cells","subitem_subject_scheme":"Other"},{"subitem_subject":"neuroimmune axis","subitem_subject_scheme":"Other"},{"subitem_subject":"nociceptin","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Opioids and the neuroimmune axis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Opioids and the neuroimmune axis"}]},"item_type_id":"3","owner":"3","path":["643"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-18"},"publish_date":"2009-09-18","publish_status":"0","recid":"3630","relation_version_is_last":true,"title":["Opioids and the neuroimmune axis"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T06:42:46.462327+00:00"}