@article{oai:hirosaki.repo.nii.ac.jp:00003631,
 author = {Hasan, Kazi N. and Shoji, Masaru and Sugimoto, Kazuhiro and Tsutaya, Shoji and Matsuda, Eriko and Kudo, Ryoko and Saito, Junko and Nakaji, Shigeyuki and Suda, Toshihiro and Yasujima, Minoru},
 issue = {Supplement},
 journal = {弘前医学},
 month = {Nov},
 note = {application/pdf, Candidate gene SNP study is a promising genetic approaches to complex common disorders. Argininevasopressin （AVP）, a peptide hormone released from the posterior pituitary, has been suggested to play importantroles in the regulation of blood pressure, glycogenolysis and platelet aggregation through G protein coupled V1areceptor （V1aR）. Thus, polymorphisms in the V1aR gene have been prospective as possible genetic markers foressential hypertension, type 2 diabetes mellitus and divergent platelet aggregation response to AVP. We identifi ed 4novel single nucleotide polymorphisms（ SNPs） in the promoter region of the V1aR gene and named according to theupstream locations such as, -6951G/A, -4112A/T, -3860T/C, and -242C/T. We investigated the association of 4 SNPs ofthe V1aR gene in 365 hypertensive and 255 healthy subjects, 186 T2DM patients and 188 non-diabetic control subjects（CS）, and 33 young healthy volunteers living in the Aomori prefecture. Signifi cant association was identifi ed betweenSNP at -6951 and hypertension in nonobese individuals, at -6951 and type 2 diabetes mellitus. Positive association wasalso identifi ed between nonobese hypertension and haplotype H3. Signifi cant association was demonstrated betweenSNP at -6951 and glycemic status in young healthy subjects. However, there was no signifi cant association in the AVPinducedplatelet aggregation with V1aR gene variants. The study suggests V1aR gene variants as increased riskfor hypertension in nonobese and type 2 diabetes mellitus in the Aomori population; however, might not be useful asgenetic markers for platelet aggregation heterogeneity., 弘前医学. 59(Suppl.), 2007, p.S119-S127},
 pages = {S119--S127},
 title = {V1a vasopressin receptor gene single nucleotide polymorphism and essential hypertension, type 2 diabetes mellitus and platelet aggregation},
 volume = {59},
 year = {2007}
}