{"created":"2023-05-15T09:02:45.880577+00:00","id":3631,"links":{},"metadata":{"_buckets":{"deposit":"87c08d8e-332e-47c9-8f07-88a30230c773"},"_deposit":{"created_by":3,"id":"3631","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3631"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003631","sets":["557:561:643"]},"author_link":["11474","11849","11853","11138","11855","11854","11472","11852","11473","11471"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S127","bibliographicPageStart":"S119","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Candidate gene SNP study is a promising genetic approaches to complex common disorders. Argininevasopressin （AVP）, a peptide hormone released from the posterior pituitary, has been suggested to play importantroles in the regulation of blood pressure, glycogenolysis and platelet aggregation through G protein coupled V1areceptor （V1aR）. Thus, polymorphisms in the V1aR gene have been prospective as possible genetic markers foressential hypertension, type 2 diabetes mellitus and divergent platelet aggregation response to AVP. We identifi ed 4novel single nucleotide polymorphisms（ SNPs） in the promoter region of the V1aR gene and named according to theupstream locations such as, -6951G/A, -4112A/T, -3860T/C, and -242C/T. We investigated the association of 4 SNPs ofthe V1aR gene in 365 hypertensive and 255 healthy subjects, 186 T2DM patients and 188 non-diabetic control subjects（CS）, and 33 young healthy volunteers living in the Aomori prefecture. Signifi cant association was identifi ed betweenSNP at -6951 and hypertension in nonobese individuals, at -6951 and type 2 diabetes mellitus. Positive association wasalso identifi ed between nonobese hypertension and haplotype H3. Signifi cant association was demonstrated betweenSNP at -6951 and glycemic status in young healthy subjects. However, there was no signifi cant association in the AVPinducedplatelet aggregation with V1aR gene variants. The study suggests V1aR gene variants as increased riskfor hypertension in nonobese and type 2 diabetes mellitus in the Aomori population; however, might not be useful asgenetic markers for platelet aggregation heterogeneity.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59(Suppl.), 2007, p.S119-S127","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Laboratory Medicine, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Laboratory Medicine, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Clinical Laboratory, Hirosaki University Hospital"},{"subitem_text_value":"Department of Clinical Laboratory, Hirosaki University Hospital"},{"subitem_text_value":"Department of Clinical Laboratory, Hirosaki University Hospital"},{"subitem_text_value":"Department of Clinical Laboratory, Hirosaki University Hospital"},{"subitem_text_value":"Department of Clinical Laboratory, Hirosaki University Hospital"},{"subitem_text_value":"Department of Social Medicine, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Laboratory Medicine, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hasan, Kazi N."}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shoji, Masaru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugimoto, Kazuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsutaya, Shoji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuda, Eriko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kudo, Ryoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saito, Junko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakaji, Shigeyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suda, Toshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yasujima, Minoru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_59_S119.pdf","filesize":[{"value":"239.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_59_S119.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3631/files/HirosakiMedJ_59_S119.pdf"},"version_id":"5d1ad36f-c4fb-4780-b722-4fa081dc5ed0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"vasopressin V1a receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"SNPs","subitem_subject_scheme":"Other"},{"subitem_subject":"essential hypertension","subitem_subject_scheme":"Other"},{"subitem_subject":"type 2 diabetes mellitus","subitem_subject_scheme":"Other"},{"subitem_subject":"platelets aggregation heterogeneity","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"V1a vasopressin receptor gene single nucleotide polymorphism and essential hypertension, type 2 diabetes mellitus and platelet aggregation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"V1a vasopressin receptor gene single nucleotide polymorphism and essential hypertension, type 2 diabetes mellitus and platelet aggregation"}]},"item_type_id":"3","owner":"3","path":["643"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-18"},"publish_date":"2009-09-18","publish_status":"0","recid":"3631","relation_version_is_last":true,"title":["V1a vasopressin receptor gene single nucleotide polymorphism and essential hypertension, type 2 diabetes mellitus and platelet aggregation"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:58:17.829478+00:00"}