@article{oai:hirosaki.repo.nii.ac.jp:00003632,
 author = {Tsubo, Toshihito and Fujita, Ayaka and Hashiba, Eiji and Ishihara, Hironori and Hirota, Kazuyoshi},
 issue = {Supplement},
 journal = {弘前医学},
 month = {Nov},
 note = {application/pdf, To investigated the eff ect of high volume continuous hemofi ltration（ HVHF） on the lung lesion observed
with transesophageal echocardiography （TEE） in endotoxin-induced acute lung injury in piglets. Piglets weighing
20-30kg. Interventions: After endotoxin of 20 μg/kg intravenous administration, animals were randomly assigned to
control group（ n=7） and HVHF group（ n=7）. In both group, fi ltration was performed for fi ve hours and zero balanced.
Filtration fl ow was 150 ml/hr in HVHF group and 0ml/hr in control group. The area of the lesion, resistive index
and maximal blood velocity in regional pulmonary artery were estimated using TEE. High mobility group B1 protein
（HMGB1）, cortisol and catecholamine concentrations were measured in plasma at endotoxin 5 hours. Measurements of
blood gas, hemodynamics and TEE images were obtained every hour. The value of PaO2, density area and resistive
index were 70.0±8.8 mmHg, 10.7±4.5 cm2 and 0.61±0.23 in control group and 120.4±20.3 mmHg, 3.3±2.0 cm2 and 0.88
±0.22 in HVHF group at endotoxin 5 hours respectively（ mean±SD）. PaO2 and resistive index increased, and density
area decreased in HVHF group than those of control group signifi cantly（ p<0.05, respectively）. There was signifi cant
relationship between PaO2 and density area （r=0.76, p<0.01）. There was no signifi cant diff erence in hemodynamics,
HMGB1, cortisol and catecholamines concentration in plasma and morphometry between control group and HVHF
group. In conclusion, these results suggest that non-specifi c blood purifi cation with HVHF improves arterial oxygenation
and lung image observed with TEE in endotoxin-induced acute lung injury in piglets., 弘前医学. 59(Suppl.), 2007, p.S128-S136},
 pages = {S128--S136},
 title = {Continuous venovenous hemofi ltration improves endotoxin induced lung injury in pigs : Evaluation with ultrasonography},
 volume = {59},
 year = {2007}
}