@article{oai:hirosaki.repo.nii.ac.jp:00003633,
 author = {Imaizumi, Tadaatsu and Mori, Fumiaki and Yagihashi, Norito and Kitamura, Hideo and Sashinami, Hiroshi and Suzuki, Koichi and Yamashita, Koji and Taima, Kageaki and Kubota, Kosei and Tanji, Kunikazu and Sakaki, Hirotaka and Matsumiya, Tomoh and Yoshida, Hidemi and Mariya, Yasushi and Nakane, Hajime and Tanaka, Hiroshi and Takanashi, Shingo and Wakabayashi, Koichi and Yagihashi, Soroku and Nakane, Akio and Ito, Etsuro and Okumura, Ken and Kimura, Hiroto and Satoh, Kei},
 issue = {Supplement},
 journal = {弘前医学},
 month = {Nov},
 note = {application/pdf, Retinoic acid-inducible gene-I （RIG-I） is a cytoplasmic protein regarded as putative RNA helicase.Immunohistochemical studies revealed high levels of RIG-I expression in epidermic cells in psoriasis, in macrophagesin atherosclerotic lesions and in glomeruli of lupus nephritis. RIG-I expression was also demonstrated in macrophagesand vascular endothelial cells in experimental animals with Listeria or Hanta virus infection. In vitro studies using cellcultures revealed the expression of RIG-I, in various cells including endothelial cells, macrophages and astroglial cells, inresponse to the stimulation with cytokines, lipopolysaccharide, double-stranded RNA, Listeria monocytogenes, etc. Thestudies employing the overexpression or RNA interference suggested that RIG-I is involved in the regulation of cytokineexpression including CXCL10/IP-10 and CCL5/RANTES. These results suggest that RIG-I constitutes a part of theintracellular pathway for the regulation of infl ammatory and immune responses., 弘前医学. 59(Suppl.), 2007, p.S137-S142},
 pages = {S137--S142},
 title = {Retinoic acid-inducible gene-I（ RIG-I） and diseases},
 volume = {59},
 year = {2007}
}