{"created":"2023-05-15T09:02:46.013954+00:00","id":3633,"links":{},"metadata":{"_buckets":{"deposit":"832179c3-96f3-4ab9-a5eb-54c7ea433be9"},"_deposit":{"created_by":3,"id":"3633","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3633"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003633","sets":["557:561:643"]},"author_link":["11463","11094","11870","11872","11866","11842","11868","11874","11869","11512","11875","11863","11458","11506","9403","11871","11876","11865","7528","11862","11459","9404","10562","11867"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S142","bibliographicPageStart":"S137","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":" Retinoic acid-inducible gene-I （RIG-I） is a cytoplasmic protein regarded as putative RNA helicase.Immunohistochemical studies revealed high levels of RIG-I expression in epidermic cells in psoriasis, in macrophagesin atherosclerotic lesions and in glomeruli of lupus nephritis. RIG-I expression was also demonstrated in macrophagesand vascular endothelial cells in experimental animals with Listeria or Hanta virus infection. In vitro studies using cellcultures revealed the expression of RIG-I, in various cells including endothelial cells, macrophages and astroglial cells, inresponse to the stimulation with cytokines, lipopolysaccharide, double-stranded RNA, Listeria monocytogenes, etc. Thestudies employing the overexpression or RNA interference suggested that RIG-I is involved in the regulation of cytokineexpression including CXCL10/IP-10 and CCL5/RANTES. These results suggest that RIG-I constitutes a part of theintracellular pathway for the regulation of infl ammatory and immune responses.\n","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59(Suppl.), 2007, p.S137-S142","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.8","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Vascular Biology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Molecular Pathology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Dermatology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Pediatrics, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Vascular Biology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Internal, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Dentistry and Oral, Surgery, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Vascular Biology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Dermatology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Dermatology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Pediatrics, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Internal, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Pediatrics, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Internal, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Dentistry and Oral, Surgery, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Vascular Biology, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Imaizumi, Tadaatsu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Mori, Fumiaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yagihashi, Norito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitamura, Hideo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sashinami, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamashita, Koji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Taima, Kageaki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kubota, Kosei"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Tanji, Kunikazu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Sakaki, Hirotaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsumiya, Tomoh"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Yoshida, Hidemi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mariya, Yasushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakane, Hajime"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takanashi, 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diseases"}]},"item_type_id":"3","owner":"3","path":["643"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-18"},"publish_date":"2009-09-18","publish_status":"0","recid":"3633","relation_version_is_last":true,"title":["Retinoic acid-inducible gene-I（ RIG-I） and diseases"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:01:15.347734+00:00"}