{"created":"2023-05-15T09:02:46.080220+00:00","id":3634,"links":{},"metadata":{"_buckets":{"deposit":"1fd4e040-370a-49ff-9aec-e03f09d117a7"},"_deposit":{"created_by":3,"id":"3634","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3634"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003634","sets":["557:561:643"]},"author_link":["9403","11878","11869","11877","9404"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S146","bibliographicPageStart":"S143","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"NEDD8 is developmentally down-regulated ubiquitin-like protein, which can conjugate covalently to their  target proteins. Recently, we identifi ed NUB1 as a NEDD8-interacting protein, which is composed of 601 amino acid  residues with a calculated molecular mass of 69.1 kDa. More recently, we showed that NUB1 is an interferon-induced  protein and also recruits NEDD8 to the proteasome for degradation. Here, we performed a yeast two-hybrid screening  using NUB1 as bait and isolated the cDNA of synphilin-1 from a human testis cDNA library. Synphilin-1 is a major  component of inclusion bodies found in the brains of patients with α-synucleinopathies, including Parkinson’s disease.  Our biochemical study showed that NUB1 directly interacts with synphilin-1 through its NEDD8-binding site. In  addition, our immunohistochemical study showed that NUB1, as well as synphilin-1, accumulates in the inclusion bodies  found in the brains of patients with α-synucleinopathies. These fi ndings imply that NUB1 plays a role in the formation  of synphilin-1-positive inclusions. ","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59(Suppl.), 2007, p.S143-S146","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.4","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Pathology, Brain Research Institute, University of Niigata, Niigata"},{"subitem_text_value":"Department of Cardiology, The University of Texas"},{"subitem_text_value":"Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tanji, Kunikazu"}],"nameIdentifiers":[{"nameIdentifier":"11869","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"314","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/314_ja.html"}]},{"creatorNames":[{"creatorName":"Mori, Fumiaki"}],"nameIdentifiers":[{"nameIdentifier":"9404","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"11877","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kamitani, Tetsu"}],"nameIdentifiers":[{"nameIdentifier":"11878","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakabayashi, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"9403","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_59_S143.pdf","filesize":[{"value":"641.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_59_S143.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3634/files/HirosakiMedJ_59_S143.pdf"},"version_id":"ed57b450-5570-4cd1-8eeb-1c2ca76afb69"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"α-synucleinopathies","subitem_subject_scheme":"Other"},{"subitem_subject":"ubiquitin","subitem_subject_scheme":"Other"},{"subitem_subject":"NEDD8","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The role of NEDD8 Ultimate Buster 1, NUB1, in neurodegenerative α-synucleinopathies","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The role of NEDD8 Ultimate Buster 1, NUB1, in neurodegenerative α-synucleinopathies"}]},"item_type_id":"3","owner":"3","path":["643"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-18"},"publish_date":"2009-09-18","publish_status":"0","recid":"3634","relation_version_is_last":true,"title":["The role of NEDD8 Ultimate Buster 1, NUB1, in neurodegenerative α-synucleinopathies"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T12:06:24.970184+00:00"}