@article{oai:hirosaki.repo.nii.ac.jp:00003635,
 author = {Suzuki, Yasuyuki and Daitoku, Kazuyuki and Minakawa, Masahito and Fukui, Kozo and Fukuda, Ikuo},
 issue = {Supplement},
 journal = {弘前医学},
 month = {Nov},
 note = {application/pdf, We have proved that Sivelestat preserved lung function after cardiopulmonary bypass（ CPB） in the rabbit  model. We now report the therapeutic efficacy of Sivelestat in the clinical case. From July 2005, 16 patients who  underwent aortic arch replacements were enrolled in this study. Diagnosis included dissected aortic aneurysm in 6  patients, true aortic arch aneurysm in 8, and traumatic aortic arch aneurysm in 1 patient. We randomly divided these  patients into two groups. In the Pre-Group（ Pre:n=8）, infusion of Sivelestat（ 0.2mg/kg/hr） was started before the  operation; in the Post-Group（ Post:n=8）, it was started after the operation. Serum elastase activity, interleukin-8（ IL-8） levels were measured before the operation, before cessation of CPB and at the end of operation. Blood gas analyses were  measured before the operation, at one and three hours after the CPB and the next morning. Because the preoperative  P/F ratio（ arterial PO2/FiO2） varies with each case, the value of the P/F ratio at one hour after the CPB was calculated  for 100%. Elastase activity of both groups were increased at the end of CPB（ Pre:8.9±10.6, Post:4.6± 3.5）, then returned  to baseline level at end of operation（ NS）. IL-8 of both groups were increased at end of CPB, then in the Pre-Group  decreased to 59.3± 25.0 pg/ml, but in the Post-Group increased to 97.9±45.7 pg/ml（ p=0.09）. The P/F ratio in the Pre- Group was well maintained from post CPB to next morning, but in the Post-Group was decreased three hours after the  CPB （p<0.05）. In conclusion, these fi ndings showed that Sivelestat reduced the infl ammatory reaction associated with  cardiopulmonary bypass, and prevented the pulmonary dysfunction caused by infl ammatory reaction., 弘前医学. 59(Suppl.), 2007, p.S147-S153},
 pages = {S147--S153},
 title = {The relations of lung injury after cardiopulmonary bypass and infl ammatory reaction, especially neutrophil elastase},
 volume = {59},
 year = {2007}
}