{"created":"2023-05-15T09:02:46.166751+00:00","id":3636,"links":{},"metadata":{"_buckets":{"deposit":"cf8c9f95-9525-4bac-9e50-438e7905dbe9"},"_deposit":{"created_by":3,"id":"3636","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3636"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003636","sets":["557:561:643"]},"author_link":["11880","11881","11883","11882"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S161","bibliographicPageStart":"S154","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Chronic ultraviolet （UV） radiation results in photoaged skin characterized by deep wrinkle formation.\nRecent studies suggest that diminishment of anchoring fi brils（ AF）, stabilizing the association of the basement membrane\nto the underlying dermis, are involved in photoaged skin. Expression of COL7A1, encoding type VII collagen that is a\nmajor component of AF, is also decreased in photoaged skin. In this study, we have investigated COL7A1 transcription\nby UV and UV-related cytokines involved in photoaged skin. Nuclear run-on assay, luciferase assay and gel shift assay\nrevealed that UV and UV-related cytokines（ TNF-α, IL-1β） tissue specifi cally downregulated COL7A1 transcription in\nepidermal keratinocytes, whereas COL7A1 transcription was upregulated by each modulator in dermal fi broblasts. The\nresponsive element of each modulator was located between nucleotide -524 and -22 of COL7A1 promoter and AP-1 and\nNF-κB families band to this region. Taken together, these data strongly suggest that the downregulation of COL7A1\ntranscription in epidermal keratinocytes, main cells expressing COL7A1 in the skin, and subsequent diminishment of AF\nare involved in photoaged skin. We also have discussed relation between these results and pathophysiology of wrinkle\nformation, characteristic feature of photoaged skin.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59(Suppl.), 2007, p.S154-S161","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.4","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Glycotechnology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Glycotechnology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Glycotechnology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Glycotechnology, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kon, Atsushi"}],"nameIdentifiers":[{"nameIdentifier":"11880","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Igarashi, Manami"}],"nameIdentifiers":[{"nameIdentifier":"11881","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamaguchi, Masanori"}],"nameIdentifiers":[{"nameIdentifier":"11882","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kojima, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"11883","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_59_S154.pdf","filesize":[{"value":"712.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_59_S154.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3636/files/HirosakiMedJ_59_S154.pdf"},"version_id":"41db84b8-5560-447a-895f-19f199911d46"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"type VII collagen","subitem_subject_scheme":"Other"},{"subitem_subject":"COL7A1","subitem_subject_scheme":"Other"},{"subitem_subject":"anchoring fibril","subitem_subject_scheme":"Other"},{"subitem_subject":"ultraviolet radiation","subitem_subject_scheme":"Other"},{"subitem_subject":"photo-aging","subitem_subject_scheme":"Other"},{"subitem_subject":"anti-aging","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Ultraviolet（ UV）-and UV-related cytokine-mediated transcriptional mechanisms of type VII collagen gene（ COL7A1） expression in the skin, with special reference to photoaged skin and anti-aging","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Ultraviolet（ UV）-and UV-related cytokine-mediated transcriptional mechanisms of type VII collagen gene（ COL7A1） expression in the skin, with special reference to photoaged skin and anti-aging"}]},"item_type_id":"3","owner":"3","path":["643"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-18"},"publish_date":"2009-09-18","publish_status":"0","recid":"3636","relation_version_is_last":true,"title":["Ultraviolet（ UV）-and UV-related cytokine-mediated transcriptional mechanisms of type VII collagen gene（ COL7A1） expression in the skin, with special reference to photoaged skin and anti-aging"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T06:42:45.601009+00:00"}