@article{oai:hirosaki.repo.nii.ac.jp:00003638,
 author = {Maruyama, Atsushi and Itoh, Ken},
 issue = {Supplement},
 journal = {弘前医学},
 month = {Nov},
 note = {application/pdf, NF-E2-related factor 2 （Nrf2） regulates the coordinate induction of phase 2 detoxifying and antioxidant
enzymes in response to xenobiotics and oxidative stress via antioxidant responsive element. Nrf2 knockout mice are
highly susceptible to the acute toxicity generated by acetaminophen, butylated hydroxytoluene or hyperoxia and to
carcinogenesis induced by benzo[a]pyrene. Recently, it becomes increasingly evident that Nrf2 also plays essential roles
in the protection against infl ammation. Nrf2 regulates the infl ammation during carrageenin-induced pleurisy and lung
infl ammation, wound healing in skin, and dextran sulfate-induced colitis. Nrf2 knockout mice are also susceptible to
endotoxin-induced septic shock and allergen-induced asthma. Using carrageenin-induced pleurisy and porcine neutrophil
elastase-induced lung injury models, we proposed that this anti-infl ammatory action of Nrf2 relies on the activities in
macrophages. In macrophages, Nrf2 modulates the infl ammatory response by up-regulating a range of anti-oxidative and
anti-infl ammatory enzymes, such as CD36 and secretory leukoprotease inhibitor（ SLPI）. CD36 is a macrophage class
B scavenger receptor involved in the uptake of apoptotic neutrophils and microorganisms such as Staphylococcus aureus.
Thus, Nrf2 may play important roles in the protection of infl ammation and innate immune response., 弘前医学. 59(Suppl.), 2007, p.S167-S171},
 pages = {S167--S171},
 title = {The role of Nrf2 in the protection against infl ammation and innate immunity},
 volume = {59},
 year = {2007}
}